A preterm infant with early onset Morganella morganii sepsis was treated with cefotaxime and gentamicin after confirmation of antimicrobial susceptibility. The infant developed persistent ventriculitis caused by the emergence of a cefotaxime-resistant Morganella variant with derepression of its AmpC β-lactamase. When choosing antibiotic therapy, the risk of development of resistance to cephalosporins should be considered in infections caused by M. morganii and other Gram-negative organisms with inducible AmpC β-lactamases.
|Number of pages||2|
|Journal||Pediatric Infectious Disease Journal|
|Publication status||Published - Apr 2006|
Copyright 2008 Elsevier B.V., All rights reserved.
- AmpC β-lactamases
- Morganella morganii