Early onset Morcanella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by derepression of AmpC β-lactamase production

Ajay K. Sinha*, Stephen T. Kempley, Elizabeth Price, Bal K. Sharma, David Livermore

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

A preterm infant with early onset Morganella morganii sepsis was treated with cefotaxime and gentamicin after confirmation of antimicrobial susceptibility. The infant developed persistent ventriculitis caused by the emergence of a cefotaxime-resistant Morganella variant with derepression of its AmpC β-lactamase. When choosing antibiotic therapy, the risk of development of resistance to cephalosporins should be considered in infections caused by M. morganii and other Gram-negative organisms with inducible AmpC β-lactamases.

Original languageEnglish
Pages (from-to)376-377
Number of pages2
JournalPediatric Infectious Disease Journal
Volume25
Issue number4
DOIs
Publication statusPublished - Apr 2006

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • AmpC β-lactamases
  • Morganella morganii
  • Newborn
  • Sepsis
  • β-lactamases

Fingerprint

Dive into the research topics of 'Early onset Morcanella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by derepression of AmpC β-lactamase production'. Together they form a unique fingerprint.

Cite this