Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

on behalf of the CHERUB Investigators

doi:10.1097/QAD.0000000000001565

Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

on behalf of the CHERUB Investigators

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

Original language	English
Pages (from-to)	1847-1851
Number of pages	5
Journal	AIDS
Volume	31
Issue number	13
DOIs	https://doi.org/10.1097/QAD.0000000000001565
Publication status	Published - 24 Aug 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV reservoir
early antiretroviral therapy
perinatally infected children

Access to Document

10.1097/QAD.0000000000001565

Cite this

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title = "Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection",

abstract = "The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.",

keywords = "HIV reservoir, early antiretroviral therapy, perinatally infected children",

author = "\{on behalf of the CHERUB Investigators\} and Caroline Foster and Matthew Pace and Steve Kaye and Emily Hopkins and Mathew Jones and Nicola Robinson and Christine Mant and John Cason and Sarah Fidler and John Frater",

year = "2017",

month = aug,

day = "24",

doi = "10.1097/QAD.0000000000001565",

language = "English",

volume = "31",

pages = "1847--1851",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "13",

}

TY - JOUR

T1 - Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

AU - on behalf of the CHERUB Investigators

AU - Foster, Caroline

AU - Pace, Matthew

AU - Kaye, Steve

AU - Hopkins, Emily

AU - Jones, Mathew

AU - Robinson, Nicola

AU - Mant, Christine

AU - Cason, John

AU - Fidler, Sarah

AU - Frater, John

PY - 2017/8/24

Y1 - 2017/8/24

N2 - The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

AB - The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

KW - HIV reservoir

KW - early antiretroviral therapy

KW - perinatally infected children

UR - https://www.scopus.com/pages/publications/85020727262

U2 - 10.1097/QAD.0000000000001565

DO - 10.1097/QAD.0000000000001565

M3 - Article

C2 - 28609403

AN - SCOPUS:85020727262

SN - 0269-9370

VL - 31

SP - 1847

EP - 1851

JO - AIDS

JF - AIDS

IS - 13

ER -

Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

Abstract

Bibliographical note

UN SDGs

Keywords

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