Dynamics of raltegravir resistance profile in an HIV type 2-infected patient

Li Xu*, Jane Anderson, Nigel Garrett, Bridget Ferns, Adrian Wildfire, Pamela Cook, Judith Workman, Susan Graham, Erasmus Smit

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The evolutionary dynamics of RAL resistance in the HIV-2 virus were examined through population and clonal sequence analysis of the IN from baseline, during treatment, and after stopping RAL therapy. The treatment failure of an RAL regimen in the HIV-2 patient studied was associated with the emergence of mutations via the N155H resistance pathway and subsequent switching to the Y143C mutational route. This study has also identified four novel secondary mutations, Q91R, S147G, A153G, and M183I, not previously reported in HIV-1 patients failing RAL therapy. Resistant variants involving the Y143C pathway were noted to have persisted beyond 4 weeks following the cessation of RAL therapy. All resistance-associated mutations were lost at 20 weeks after stopping RAL therapy. Our findings provide evidence supporting the supposition that substantial cross-resistance between strand transfer IN-Is is likely in HIV-2 as shown in HIV-1.

Original languageEnglish
Pages (from-to)843-847
Number of pages5
JournalAIDS Research and Human Retroviruses
Issue number8
Publication statusPublished - 1 Aug 2009
Externally publishedYes


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