Dynamics of HIV type 1 recombination following superinfection

Fransje A. Koning; Anjna Badhan; Simon Shaw; Martin Fisher; Jean Mbisa; Patricia Cane

doi:10.1089/aid.2013.0009

Dynamics of HIV type 1 recombination following superinfection

Fransje A. Koning^*, Anjna Badhan, Simon Shaw, Martin Fisher, Jean Mbisa, Patricia Cane

^*Corresponding author for this work

HIV STI General

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.

Original language	English
Pages (from-to)	963-970
Number of pages	8
Journal	AIDS Research and Human Retroviruses
Volume	29
Issue number	6
DOIs	https://doi.org/10.1089/aid.2013.0009
Publication status	Published - 1 Jun 2013

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AU - Badhan, Anjna

AU - Shaw, Simon

AU - Fisher, Martin

AU - Mbisa, Jean

AU - Cane, Patricia

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AB - There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.

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Dynamics of HIV type 1 recombination following superinfection

Abstract

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