Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020

Anika Singanayagam; Monika Patel; Andre Charlett; Jamie Lopez Bernal; Vanessa Saliba; Joanna Ellis; Shamez Ladhani; Maria Zambon; Robin Gopal

doi:10.2807/1560-7917.ES.2020.25.32.2001483

Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020

Anika Singanayagam, Monika Patel, Andre Charlett, Jamie Lopez Bernal, Vanessa Saliba, Joanna Ellis, Shamez Ladhani, Maria Zambon^*, Robin Gopal

^*Corresponding author for this work

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Abstract

Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct>35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.

Original language	English
Journal	Eurosurveillance
Volume	25
Issue number	32
DOIs	https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483
Publication status	Published - 13 Aug 2020

Bibliographical note

Funding Information: No funding information.

Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made.

Publisher Copyright: This article is copyright of the authors or their affiliated institutions, 2020.

Citation: Singanayagam Anika, Patel Monika, Charlett Andre, Lopez Bernal Jamie, Saliba Vanessa, Ellis Joanna, Ladhani Shamez, Zambon Maria, Gopal Robin. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020. Euro Surveill. 2020;25(32)

DOI: https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483

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abstract = "Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct>35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.",

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AU - Saliba, Vanessa

AU - Ellis, Joanna

AU - Ladhani, Shamez

AU - Zambon, Maria

AU - Gopal, Robin

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Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020

Abstract

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