Do differences in panton-valentine leukocidin production among international methicillin-resistant Staphylococcus aureus clones affect disease presentation and severity?

Eve Boakes, Angela M. Kearns*, Cederic Badiou, Gerard Lina, Robert L. Hill, Matthew J. Ellington

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)

    Abstract

    Panton-Valentine leukocidin (PVL) production by methicillin-resistant Staphylococcus aureus (MRSA) was determined in vitro using the enzyme-linked immunosorbent assay (ELISA), and associations with clinical presentation and bacterial genetic characteristics were examined. PVL production ranged from 0.02 to 4.865 μg/ml and correlated with a multilocus sequence type (MLST) clonal complex associated with specific PVL phage types. A relationship between PVL production and clinical presentation or patient demographics could not be demonstrated.

    Original languageEnglish
    Pages (from-to)1773-1776
    Number of pages4
    JournalJournal of Clinical Microbiology
    Volume50
    Issue number5
    DOIs
    Publication statusPublished - May 2012

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