DNA Methylation Changes in the IL‐I (2F) Chromosomal Region of Some Radiation‐Induced Acute Myeloid Leukaemias Carrying Chromosome 2 Rearrangements

Andrew Silver; Andrew George; Walter Masson; George Breckon; Julie Adam; Roger Cox

doi:10.1002/gcc.2870030508

DNA Methylation Changes in the IL‐I (2F) Chromosomal Region of Some Radiation‐Induced Acute Myeloid Leukaemias Carrying Chromosome 2 Rearrangements

Andrew Silver, Andrew George, Walter Masson, George Breckon, Julie Adam, Roger Cox^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (IL)‐l α and β map to this region, and the β gene is deregulated in some AMLs. Using pulsed‐fleld gel electrophoresis techniques, we show here that an 800 kb 2F region encoding IL‐l α and β is not obviously rearranged in six leukaemias carrying chromosome 2 abnormalities. However, changes in IL‐I region DNA methylation in three leukaemias may be consistent with loss of hypermethylated sequences from one chromosome copy. These possible 2F region losses are discussed in relation to genomic imprinting and its potential role in murine myeloid leukaemogenesis.

Original language	English
Pages (from-to)	376-381
Number of pages	6
Journal	Genes Chromosomes and Cancer
Volume	3
Issue number	5
DOIs	https://doi.org/10.1002/gcc.2870030508
Publication status	Published - Sept 1991

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title = "DNA Methylation Changes in the IL‐I (2F) Chromosomal Region of Some Radiation‐Induced Acute Myeloid Leukaemias Carrying Chromosome 2 Rearrangements",

abstract = "Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (IL)‐l α and β map to this region, and the β gene is deregulated in some AMLs. Using pulsed‐fleld gel electrophoresis techniques, we show here that an 800 kb 2F region encoding IL‐l α and β is not obviously rearranged in six leukaemias carrying chromosome 2 abnormalities. However, changes in IL‐I region DNA methylation in three leukaemias may be consistent with loss of hypermethylated sequences from one chromosome copy. These possible 2F region losses are discussed in relation to genomic imprinting and its potential role in murine myeloid leukaemogenesis.",

author = "Andrew Silver and Andrew George and Walter Masson and George Breckon and Julie Adam and Roger Cox",

year = "1991",

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AU - George, Andrew

AU - Masson, Walter

AU - Breckon, George

AU - Adam, Julie

AU - Cox, Roger

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N2 - Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (IL)‐l α and β map to this region, and the β gene is deregulated in some AMLs. Using pulsed‐fleld gel electrophoresis techniques, we show here that an 800 kb 2F region encoding IL‐l α and β is not obviously rearranged in six leukaemias carrying chromosome 2 abnormalities. However, changes in IL‐I region DNA methylation in three leukaemias may be consistent with loss of hypermethylated sequences from one chromosome copy. These possible 2F region losses are discussed in relation to genomic imprinting and its potential role in murine myeloid leukaemogenesis.

AB - Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (IL)‐l α and β map to this region, and the β gene is deregulated in some AMLs. Using pulsed‐fleld gel electrophoresis techniques, we show here that an 800 kb 2F region encoding IL‐l α and β is not obviously rearranged in six leukaemias carrying chromosome 2 abnormalities. However, changes in IL‐I region DNA methylation in three leukaemias may be consistent with loss of hypermethylated sequences from one chromosome copy. These possible 2F region losses are discussed in relation to genomic imprinting and its potential role in murine myeloid leukaemogenesis.

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DNA Methylation Changes in the IL‐I (2F) Chromosomal Region of Some Radiation‐Induced Acute Myeloid Leukaemias Carrying Chromosome 2 Rearrangements

Abstract

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