TY - JOUR
T1 - Distribution of espI among clinical enterohaemorrhagic and enteropathogenic Escherichia coli isolates
AU - Mundy, Rosanna
AU - Jenkins, Claire
AU - Yu, Jun
AU - Smith, Henry
AU - Frankel, Gad
PY - 2004/11
Y1 - 2004/11
N2 - Enterohaemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli are important diarrhoeagenic pathogens; infection is dependent on translocation of a number of type III effector proteins. Until recently all the known effectors were encoded on the LEE pathogenicity island, which also encodes the adhesin intimin and the type III secretion apparatus. Recently, a novel non-LEE effector protein, EspI/NleA, which is required for full virulence in vivo and is encoded on a prophage, was identified. The aim of this study was to determine the distribution of espI among clinical EHEC and EPEC isolates, espI was detected in 86% and 53% of LEE+ EHEC and EPEC strains, respectively. Moreover, the espI gene was more commonly found in patients suffering from a more severe disease.
AB - Enterohaemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli are important diarrhoeagenic pathogens; infection is dependent on translocation of a number of type III effector proteins. Until recently all the known effectors were encoded on the LEE pathogenicity island, which also encodes the adhesin intimin and the type III secretion apparatus. Recently, a novel non-LEE effector protein, EspI/NleA, which is required for full virulence in vivo and is encoded on a prophage, was identified. The aim of this study was to determine the distribution of espI among clinical EHEC and EPEC isolates, espI was detected in 86% and 53% of LEE+ EHEC and EPEC strains, respectively. Moreover, the espI gene was more commonly found in patients suffering from a more severe disease.
UR - https://www.scopus.com/pages/publications/11144231319
U2 - 10.1099/jmm.0.45684-0
DO - 10.1099/jmm.0.45684-0
M3 - Article
C2 - 15496394
AN - SCOPUS:11144231319
SN - 0022-2615
VL - 53
SP - 1145
EP - 1149
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
IS - 11
ER -