Diesel exhaust particle and dust mite induced airway inflammation is modified by cerium dioxide nanoparticles

Kirsty Meldrum, Sarah Robertson, Isabella Romer Roche, Timothy Marczylo, Timothy Gant, Rachel Smith, Teresa D. Tetley, Martin Leonard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Cerium dioxide nanoparticles (CeO2NPs) have been used as diesel fuel-borne catalysts for improved efficiency and pollutant emissions. Concerns that such material may influence diesel exhaust particle (DEP) effects within the lung upon inhalation, prompted us to examine particle responses in mice in the presence and absence of the common allergen house dust mite (HDM). Repeated intranasal instillation of combined HDM and DEP increased airway mucin, eosinophils, lymphocytes, IL-5, IL-13, IL-17A and plasma IgE, which were further increased with CeO2NPs co-exposure. A single co-exposure of CeO2NPs and DEP after repeated HDM exposure increased macrophage and IL-17A levels above DEP induced levels. CeO2NPs exposure in the absence of HDM also resulted in increased levels of plasma IgE and airway mucin staining, changes not observed with repeated DEP exposure alone. These observations indicate that CeO2NPs can modify exhaust particulate and allergen induced inflammatory events in the lung with the potential to influence conditions such as allergic airway disease.

Original languageEnglish
Article number103273
JournalEnvironmental Toxicology and Pharmacology
Volume73
Early online date11 Oct 2019
DOIs
Publication statusPublished - Jan 2020

Bibliographical note

Financial Information: This research was funded through Public Health England’s Asthma Program and PhD Studentship fund. The authors would like to thank Kevin Whitehill and Chris Ottaway for their help with animal studies.

Open Access: No Open Access licence

Publisher Copyright: © 2019 Elsevier B.V. All rights reserved.

Citation: Kirsty Meldrum, Sarah Robertson, Isabella Römer, Tim Marczylo, Timothy W. Gant, Rachel Smith, Teresa D. Tetley, Martin O. Leonard, Diesel exhaust particle and dust mite induced airway inflammation is modified by cerium dioxide nanoparticles, Environmental Toxicology and Pharmacology, Volume 73, 2020, 103273, ISSN 1382-6689.

DOI: https://doi.org/10.1016/j.etap.2019.103273.

Keywords

  • Allergic airway disease
  • Lung
  • Nanoparticles
  • Particulate pollutants

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