Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review

Matthew F. Chersich; Johanna Takkinen; Caroline Charlier; Alexandre Leclercq; Paul E. Adams; Gauri Godbole; Ursula Altmeyer; Ingrid H.M. Friesema; Lisa Labbé Sandelin; Lorna Jenkin; Luigi Fontana; Raffaella Aldigeri; Francois Venter; Stanley M.F. Luchters; Marc Lecuit; Luca Cimino

doi:10.1080/09273948.2016.1276788

Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review

Matthew F. Chersich^*, Johanna Takkinen, Caroline Charlier, Alexandre Leclercq, Paul E. Adams, Gauri Godbole, Ursula Altmeyer, Ingrid H.M. Friesema, Lisa Labbé Sandelin, Lorna Jenkin, Luigi Fontana, Raffaella Aldigeri, Francois Venter, Stanley M.F. Luchters, Marc Lecuit, Luca Cimino

^*Corresponding author for this work

NIS: Gastrointestinal Infections

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis. Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded. Results: Most cases occurred in 2000–2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5–17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes. Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition’s rarity and variation in treatment makes it difficult to identify optimum therapy.

Original language	English
Pages (from-to)	508-517
Number of pages	10
Journal	Ocular Immunology and Inflammation
Volume	26
Issue number	4
DOIs	https://doi.org/10.1080/09273948.2016.1276788
Publication status	Published - 19 May 2018

Bibliographical note

Funding Information:
We acknowledge the invaluable assistance of Devind Peter and staff at the Wits Health Sciences Library, as well as Ashar Dhana and Langelihle Mlotshwa in locating articles for the review. MFC thanks colleagues and family for their support over the course of his case of the condition. The authors are grateful to Hanno Olinger, Jonas I. Liechti and Nicole Schmidt who translated the German and French articles. We acknowledge the CDC Listeria Initiative, Atlanta, GA: US Department of Health and Human Services, CDC as the data source for cases in the review (data received on 10/27/2015). The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

Publisher Copyright:
© Taylor & Francis Group, LLC.

Keywords

Endophthalmitis
Listeria monocytogenes
ocular inflammation
systematic review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/09273948.2016.1276788

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Chersich, M. F., Takkinen, J., Charlier, C., Leclercq, A., Adams, P. E., Godbole, G., Altmeyer, U., Friesema, I. H. M., Labbé Sandelin, L., Jenkin, L., Fontana, L., Aldigeri, R., Venter, F., Luchters, S. M. F., Lecuit, M., & Cimino, L. (2018). Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review. Ocular Immunology and Inflammation, 26(4), 508-517. https://doi.org/10.1080/09273948.2016.1276788

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abstract = "Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis. Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded. Results: Most cases occurred in 2000–2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5–17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes. Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition{\textquoteright}s rarity and variation in treatment makes it difficult to identify optimum therapy.",

keywords = "Endophthalmitis, Listeria monocytogenes, ocular inflammation, systematic review",

author = "Chersich, {Matthew F.} and Johanna Takkinen and Caroline Charlier and Alexandre Leclercq and Adams, {Paul E.} and Gauri Godbole and Ursula Altmeyer and Friesema, {Ingrid H.M.} and {Labb{\'e} Sandelin}, Lisa and Lorna Jenkin and Luigi Fontana and Raffaella Aldigeri and Francois Venter and Luchters, {Stanley M.F.} and Marc Lecuit and Luca Cimino",

note = "Funding Information: We acknowledge the invaluable assistance of Devind Peter and staff at the Wits Health Sciences Library, as well as Ashar Dhana and Langelihle Mlotshwa in locating articles for the review. MFC thanks colleagues and family for their support over the course of his case of the condition. The authors are grateful to Hanno Olinger, Jonas I. Liechti and Nicole Schmidt who translated the German and French articles. We acknowledge the CDC Listeria Initiative, Atlanta, GA: US Department of Health and Human Services, CDC as the data source for cases in the review (data received on 10/27/2015). The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Publisher Copyright: {\textcopyright} Taylor & Francis Group, LLC.",

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doi = "10.1080/09273948.2016.1276788",

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Chersich, MF, Takkinen, J, Charlier, C, Leclercq, A, Adams, PE, Godbole, G, Altmeyer, U, Friesema, IHM, Labbé Sandelin, L, Jenkin, L, Fontana, L, Aldigeri, R, Venter, F, Luchters, SMF, Lecuit, M & Cimino, L 2018, 'Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review', Ocular Immunology and Inflammation, vol. 26, no. 4, pp. 508-517. https://doi.org/10.1080/09273948.2016.1276788

TY - JOUR

T1 - Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis

T2 - A Systematic Review

AU - Chersich, Matthew F.

AU - Takkinen, Johanna

AU - Charlier, Caroline

AU - Leclercq, Alexandre

AU - Adams, Paul E.

AU - Godbole, Gauri

AU - Altmeyer, Ursula

AU - Friesema, Ingrid H.M.

AU - Labbé Sandelin, Lisa

AU - Jenkin, Lorna

AU - Fontana, Luigi

AU - Aldigeri, Raffaella

AU - Venter, Francois

AU - Luchters, Stanley M.F.

AU - Lecuit, Marc

AU - Cimino, Luca

N1 - Funding Information: We acknowledge the invaluable assistance of Devind Peter and staff at the Wits Health Sciences Library, as well as Ashar Dhana and Langelihle Mlotshwa in locating articles for the review. MFC thanks colleagues and family for their support over the course of his case of the condition. The authors are grateful to Hanno Olinger, Jonas I. Liechti and Nicole Schmidt who translated the German and French articles. We acknowledge the CDC Listeria Initiative, Atlanta, GA: US Department of Health and Human Services, CDC as the data source for cases in the review (data received on 10/27/2015). The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Publisher Copyright: © Taylor & Francis Group, LLC.

PY - 2018/5/19

Y1 - 2018/5/19

N2 - Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis. Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded. Results: Most cases occurred in 2000–2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5–17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes. Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition’s rarity and variation in treatment makes it difficult to identify optimum therapy.

AB - Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis. Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded. Results: Most cases occurred in 2000–2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5–17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes. Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition’s rarity and variation in treatment makes it difficult to identify optimum therapy.

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KW - Listeria monocytogenes

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KW - systematic review

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DO - 10.1080/09273948.2016.1276788

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AN - SCOPUS:85011301757

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JO - Ocular Immunology and Inflammation

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SN - 0927-3948

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ER -

Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review

Abstract

Bibliographical note

Keywords

UN SDGs

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