TY - JOUR
T1 - Diabetes mellitus and latent tuberculosis infection
T2 - Baseline analysis of a large UK cohort
AU - Jackson, Charlotte
AU - Southern, Joanna
AU - Lalvani, Ajit
AU - Drobniewski, Francis
AU - Griffiths, Chris J.
AU - Lipman, Marc
AU - Bothamley, Graham H.
AU - Deeks, Jonathan J.
AU - Imran, Ambreen
AU - Kon, Onn Min
AU - Mpofu, Sithembinkosi
AU - Nikolayevskyy, Vladyslav
AU - Rees-Roberts, Melanie
AU - Sitch, Alice
AU - Sridhar, Saranya
AU - Tsou, Chuen Yan
AU - Whitworth, Hilary
AU - Abubakar, Ibrahim
N1 - Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2019. All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). Trial registration number PREDICT is registered on clinicaltrials.gov
AB - We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). Trial registration number PREDICT is registered on clinicaltrials.gov
KW - clinical epidemiology
KW - tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85047976513&partnerID=8YFLogxK
U2 - 10.1136/thoraxjnl-2017-211124
DO - 10.1136/thoraxjnl-2017-211124
M3 - Article
C2 - 29764958
AN - SCOPUS:85047976513
SN - 0040-6376
VL - 74
SP - 91
EP - 94
JO - Thorax
JF - Thorax
IS - 1
ER -