Developing vaccines against potential pandemic influenza viruses

J. M. Wood; K. G. Nicholson; Maria Zambon; R. Hinton; D. L. Major; R. W. Newman; U. Dunleavy; D. Melzack; J. S. Robertson; G. C. Schild

doi:10.1016/S0531-5131(01)00385-5

Developing vaccines against potential pandemic influenza viruses

J. M. Wood^*, K. G. Nicholson, Maria Zambon, R. Hinton, D. L. Major, R. W. Newman, U. Dunleavy, D. Melzack, J. S. Robertson, G. C. Schild

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In the event of an influenza pandemic, there will be an urgent need for a vaccine. The human infections with influenza A (H5N1) and A (H9N2) viruses served as pandemic warnings and initiated worldwide efforts to develop suitable vaccines. This was not straightforward however, due to safety considerations and many practical problems that were encountered. This is primarily on account of the three main strategies for H5 vaccine development: attenuation of the pathogenic A/Hong Kong/97 (H5N1) virus; expression of H5 haemagglutinin in baculovirus vectors; use of avirulent H5 avian viruses. Progress with H9 vaccine development is also reviewed. Over the past 2[formula omitted] years, we have learnt a great deal about our ability to respond to an influenza pandemic. Some of the improvements that could be made for the future, are summarised.

Original language	English
Pages (from-to)	751-759
Number of pages	9
Journal	International Congress Series
Volume	1219
Issue number	C
DOIs	https://doi.org/10.1016/S0531-5131(01)00385-5
Publication status	Published - 1 Oct 2001

Keywords

H5N1 vaccines
H9N2 vaccines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0531-5131(01)00385-5

Cite this

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title = "Developing vaccines against potential pandemic influenza viruses",

abstract = "In the event of an influenza pandemic, there will be an urgent need for a vaccine. The human infections with influenza A (H5N1) and A (H9N2) viruses served as pandemic warnings and initiated worldwide efforts to develop suitable vaccines. This was not straightforward however, due to safety considerations and many practical problems that were encountered. This is primarily on account of the three main strategies for H5 vaccine development: attenuation of the pathogenic A/Hong Kong/97 (H5N1) virus; expression of H5 haemagglutinin in baculovirus vectors; use of avirulent H5 avian viruses. Progress with H9 vaccine development is also reviewed. Over the past 2[formula omitted] years, we have learnt a great deal about our ability to respond to an influenza pandemic. Some of the improvements that could be made for the future, are summarised.",

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AU - Wood, J. M.

AU - Nicholson, K. G.

AU - Zambon, Maria

AU - Hinton, R.

AU - Major, D. L.

AU - Newman, R. W.

AU - Dunleavy, U.

AU - Melzack, D.

AU - Robertson, J. S.

AU - Schild, G. C.

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N2 - In the event of an influenza pandemic, there will be an urgent need for a vaccine. The human infections with influenza A (H5N1) and A (H9N2) viruses served as pandemic warnings and initiated worldwide efforts to develop suitable vaccines. This was not straightforward however, due to safety considerations and many practical problems that were encountered. This is primarily on account of the three main strategies for H5 vaccine development: attenuation of the pathogenic A/Hong Kong/97 (H5N1) virus; expression of H5 haemagglutinin in baculovirus vectors; use of avirulent H5 avian viruses. Progress with H9 vaccine development is also reviewed. Over the past 2[formula omitted] years, we have learnt a great deal about our ability to respond to an influenza pandemic. Some of the improvements that could be made for the future, are summarised.

AB - In the event of an influenza pandemic, there will be an urgent need for a vaccine. The human infections with influenza A (H5N1) and A (H9N2) viruses served as pandemic warnings and initiated worldwide efforts to develop suitable vaccines. This was not straightforward however, due to safety considerations and many practical problems that were encountered. This is primarily on account of the three main strategies for H5 vaccine development: attenuation of the pathogenic A/Hong Kong/97 (H5N1) virus; expression of H5 haemagglutinin in baculovirus vectors; use of avirulent H5 avian viruses. Progress with H9 vaccine development is also reviewed. Over the past 2[formula omitted] years, we have learnt a great deal about our ability to respond to an influenza pandemic. Some of the improvements that could be made for the future, are summarised.

KW - H5N1 vaccines

KW - H9N2 vaccines

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Developing vaccines against potential pandemic influenza viruses

Abstract

Keywords

UN SDGs

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