Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, october to december 2018

David W. Eyre*, Katy Town, Teresa Street, Leanne Barker, Nicholas Sanderson, Michelle Cole, Hamish Mohammed, Rachel Pitt-Kendall, Maya Gobin, Charles Irish, Daniel Gardiner, James Sedgwick, Charles Beck, John Saunders, Deborah Turbitt, Clare Cook, Nicholas Phin, Bavithra Nathan, Paddy Horner, Helen Fifer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

We describe detection in the United Kingdom (UK) of the drug-resistant Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance. Two female patients developed infection following contact with UK-resident men from the same sexual network linked to travel to Ibiza, Spain. One case failed treatment with ceftriaxone, and azithromycin and gentamicin, before successful treatment with ertapenem. Both isolates had indistinguishable whole-genome sequences. Urgent action is essential to contain this drug-resistant strain.

Original languageEnglish
Article number1900147
JournalEurosurveillance
Volume24
Issue number10
DOIs
Publication statusPublished - 7 Mar 2019

Bibliographical note

Funding Information:
This work was supported by the National Institute for Health Research Oxford Biomedical Research Centre and the Health Protection Research Unit (NIHR HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at the University of Oxford in partnership with Public Health England (PHE) [HPRU-2012-10041]. DWE is a Big Data Institute Robertson Fellow.

Funding Information:
This work was supported by the National Institute for Health Research Oxford Biomedical Research Centre and the Health Protection Research Unit (NIHR HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at the University of Oxford in partnership with Public Health England (PHE) [HPRU-2012-10041]. DWE is a Big Data Institute Robertson Fellow. We acknowledge the contribution of several unlisted authors, whose names have been withheld to preserve patient confidentially. We would also like to acknowledge Magnus Unemo, Daniel Golparian and Béatrice Berçot for providing sequencing data from previously published studies.

Publisher Copyright:
© 2019, European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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