Deposition and clearance of inhaled particles in the human nasal passage

M. D. Dorrian; J. R.H. Smith; M. J. Youngman; M. R. Bailey; G. Etherington; A. L. Shutt

doi:10.1016/0021-8502(96)00313-8

Deposition and clearance of inhaled particles in the human nasal passage

M. D. Dorrian^*, J. R.H. Smith, M. J. Youngman, M. R. Bailey, G. Etherington, A. L. Shutt

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

Abstract

Particle deposition in, and clearance from, the human nasal passage investigations are under way and will last for three years. Monodisperse particles ranging from 0.6 to greater than 30 μm are inhaled under three different breathing regimes; sitting and light exercise as defined in ICRP Publication 66, and controlled breathing. Deposition in the nasal passages are measured and clearance followed up for several days from the end of a single acute inhalation. Nose blow samples will be measured to study the assumption in ICRP Publication 66 that all clearance from the anterior region of the nose is intrinsic. Furthermore, the extent of inter-subject variation will be determined.

Original language	English
Pages (from-to)	S481
Journal	Journal of Aerosol Science
Volume	27
Issue number	Suppl 1
DOIs	https://doi.org/10.1016/0021-8502(96)00313-8
Publication status	Published - 1996
Event	Proceedings of the 1996 European Aerosol Conference - Delft, Neth Duration: 9 Sep 1996 → 12 Sep 1996

Bibliographical note

Funding Information:
This work was partiallysupportedby the CEC under contract FI3P-CT920064a.

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10.1016/0021-8502(96)00313-8

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title = "Deposition and clearance of inhaled particles in the human nasal passage",

abstract = "Particle deposition in, and clearance from, the human nasal passage investigations are under way and will last for three years. Monodisperse particles ranging from 0.6 to greater than 30 μm are inhaled under three different breathing regimes; sitting and light exercise as defined in ICRP Publication 66, and controlled breathing. Deposition in the nasal passages are measured and clearance followed up for several days from the end of a single acute inhalation. Nose blow samples will be measured to study the assumption in ICRP Publication 66 that all clearance from the anterior region of the nose is intrinsic. Furthermore, the extent of inter-subject variation will be determined.",

author = "Dorrian, {M. D.} and Smith, {J. R.H.} and Youngman, {M. J.} and Bailey, {M. R.} and G. Etherington and Shutt, {A. L.}",

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T1 - Deposition and clearance of inhaled particles in the human nasal passage

AU - Dorrian, M. D.

AU - Smith, J. R.H.

AU - Youngman, M. J.

AU - Bailey, M. R.

AU - Etherington, G.

AU - Shutt, A. L.

N1 - Funding Information: This work was partiallysupportedby the CEC under contract FI3P-CT920064a.

PY - 1996

Y1 - 1996

N2 - Particle deposition in, and clearance from, the human nasal passage investigations are under way and will last for three years. Monodisperse particles ranging from 0.6 to greater than 30 μm are inhaled under three different breathing regimes; sitting and light exercise as defined in ICRP Publication 66, and controlled breathing. Deposition in the nasal passages are measured and clearance followed up for several days from the end of a single acute inhalation. Nose blow samples will be measured to study the assumption in ICRP Publication 66 that all clearance from the anterior region of the nose is intrinsic. Furthermore, the extent of inter-subject variation will be determined.

AB - Particle deposition in, and clearance from, the human nasal passage investigations are under way and will last for three years. Monodisperse particles ranging from 0.6 to greater than 30 μm are inhaled under three different breathing regimes; sitting and light exercise as defined in ICRP Publication 66, and controlled breathing. Deposition in the nasal passages are measured and clearance followed up for several days from the end of a single acute inhalation. Nose blow samples will be measured to study the assumption in ICRP Publication 66 that all clearance from the anterior region of the nose is intrinsic. Furthermore, the extent of inter-subject variation will be determined.

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DO - 10.1016/0021-8502(96)00313-8

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AN - SCOPUS:0030232250

VL - 27

SP - S481

JO - Journal of Aerosol Science

JF - Journal of Aerosol Science

SN - 0021-8502

IS - Suppl 1

T2 - Proceedings of the 1996 European Aerosol Conference

Y2 - 9 September 1996 through 12 September 1996

ER -

Deposition and clearance of inhaled particles in the human nasal passage

Abstract

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