TY - JOUR
T1 - Defining an extended-spectrum β-lactamase
AU - Livermore, David M.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2008/1
Y1 - 2008/1
N2 - The term 'extended-spectrum β-lactamase' (ESBL), initially' extended-broad-spectrum β-lactamase', was first coined for derivatives of TEM and SHV enzymes able to hydrolyse oxyimino-cephalosporins. These all belonged to β-lactamase functional group 2be. Subsequently, the term has been stretched to include: (i) enzymes with spectra similar to those of TEM and SHV mutants but derived from other sources, e.g., the CTX-M and VEB types; (ii) TEM and SHV mutants with borderline ESBL activity, e.g., TEM-12; and (iii) various β-lactamases conferring wider resistance than their parent types but not meeting the definition for group 2be, e.g., OXA derivatives and mutant AmpC types with increased activity against cefepime. It seems best-and pragmatic-that the term 'ESBL' retains its broad modern usage, but that should always be accompanied by mention of the enzyme's family as, e.g., in 'TEM ESBL' or 'OXA ESBL', not as a sole moniker.
AB - The term 'extended-spectrum β-lactamase' (ESBL), initially' extended-broad-spectrum β-lactamase', was first coined for derivatives of TEM and SHV enzymes able to hydrolyse oxyimino-cephalosporins. These all belonged to β-lactamase functional group 2be. Subsequently, the term has been stretched to include: (i) enzymes with spectra similar to those of TEM and SHV mutants but derived from other sources, e.g., the CTX-M and VEB types; (ii) TEM and SHV mutants with borderline ESBL activity, e.g., TEM-12; and (iii) various β-lactamases conferring wider resistance than their parent types but not meeting the definition for group 2be, e.g., OXA derivatives and mutant AmpC types with increased activity against cefepime. It seems best-and pragmatic-that the term 'ESBL' retains its broad modern usage, but that should always be accompanied by mention of the enzyme's family as, e.g., in 'TEM ESBL' or 'OXA ESBL', not as a sole moniker.
KW - CTX-M
KW - Classification
KW - ESBL
KW - Extended-spectrum β-lactamase
KW - Review
KW - SHV
KW - TEM
KW - β-Lactamases
UR - http://www.scopus.com/inward/record.url?scp=37249052235&partnerID=8YFLogxK
U2 - 10.1111/j.1469-0691.2007.01857.x
DO - 10.1111/j.1469-0691.2007.01857.x
M3 - Review article
C2 - 18154524
AN - SCOPUS:37249052235
SN - 1198-743X
VL - 14
SP - 3
EP - 10
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - SUPPL. 1
ER -