Current approaches to whole genome phylogenetic analysis.

George Sawa*, J. Dicks, Ian N. Roberts

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


It has long been known that evolutionary trees (phylogenies) can be estimated by comparing the DNA or protein sequences of homologous genes across different organisms. More recently, attempts have been made to estimate phylogenies by comparing entire genomes. These attempts have focused largely on comparisons of gene content and gene order. Many different methods have been proposed for making these comparisons. These include primarily maximum parsimony and distance methods, although more recently maximum likelihood and Bayesian methods are being developed. This paper discusses each of these approaches in turn, including their merits and limitations, and any software which is available to make use of them.

Original languageEnglish
Pages (from-to)63-74
Number of pages12
JournalBriefings in Bioinformatics
Issue number1
Publication statusPublished - Mar 2003
Externally publishedYes


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