Cumulative flying time and risk of venous thromboembolism

Peter K. Maccallum*, Deborah Ashby, Enid M. Hennessy, Louise Letley, Jeannett Martin, Shahrul Mt-Isa, Madge R. Vickers, Ken Whyte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The risk of venous thromboembolism (VTE) associated with cumulative flying time remains uncertain. In a case-control study in general practices throughout the UK, participants comprised 550 VTE cases identified from practice records and 1971 age- and gender-matched controls. Participants returned identical questionnaires asking for information including air travel details. Compared to not flying, cumulative flying time >12h within the previous 4weeks was associated with a threefold increase in the risk of VTE [odds ratio (OR) 2·75, 95% confidence interval (CI), 1·44-5·28]. Those who had flown >4h in a single leg in the previous 4weeks had twice the risk of VTE (OR 2·20, 95% CI, 1·29-3·73). These risks were no longer evident by 12weeks and were similar to those of day-case or minor surgery (OR 5·35, 95% CI, 2·15-13·33). Equivalent risks for moderate and high-risk surgery were over 30-fold (OR 36·57, 95% CI, 13·05-102·52) and 140-fold (OR 141·71, 95% CI, 19·38-1036·01) respectively. The temporary nature of the association of cumulative and long-haul air travel with VTE suggests a causal relationship. The risks of VTE in those with a higher baseline risk due to surgery, previous VTE or obesity are further increased by air travel.

Original languageEnglish
Pages (from-to)613-619
Number of pages7
JournalBritish Journal of Haematology
Issue number5
Publication statusPublished - Dec 2011
Externally publishedYes


  • Epidemiology
  • Risk factors
  • Venous thrombosis


Dive into the research topics of 'Cumulative flying time and risk of venous thromboembolism'. Together they form a unique fingerprint.

Cite this