creation of a large deletion mutant of campylobacter jejuni reveals that the lipooligosaccharide gene cluster is not required for viability

Gemma L. Marsden; Jianjun Li; Paul H. Everest; Andrew Lawson; Julian M. Ketley

doi:10.1128/JB.01397-08

creation of a large deletion mutant of campylobacter jejuni reveals that the lipooligosaccharide gene cluster is not required for viability

Gemma L. Marsden, Jianjun Li, Paul H. Everest, Andrew Lawson, Julian M. Ketley

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome of Campy- lobacter jejuni NCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.

Original language	English
Pages (from-to)	2392-2399
Number of pages	8
Journal	Journal of Bacteriology
Volume	191
Issue number	7
DOIs	https://doi.org/10.1128/JB.01397-08
Publication status	Published - Apr 2009

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abstract = "Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome of Campy- lobacter jejuni NCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.",

author = "Marsden, {Gemma L.} and Jianjun Li and Everest, {Paul H.} and Andrew Lawson and Ketley, {Julian M.}",

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AU - Everest, Paul H.

AU - Lawson, Andrew

AU - Ketley, Julian M.

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AB - Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome of Campy- lobacter jejuni NCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.

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ER -

creation of a large deletion mutant of campylobacter jejuni reveals that the lipooligosaccharide gene cluster is not required for viability

Abstract

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