Cost-effectiveness of varicella and zoster vaccination in England&Wales: Importance measures for correlated parameters

J. Bilcke; Albert Jan Van Hoek; N. Hens; M. Aerts; W. J. Edmunds; P. Beutels

doi:10.1016/j.sbspro.2010.05.142

Cost-effectiveness of varicella and zoster vaccination in England&Wales: Importance measures for correlated parameters

J. Bilcke^*
, Albert Jan Van Hoek
, N. Hens
, M. Aerts
, W. J. Edmunds
, P. Beutels

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

1 Citation (Scopus)

Abstract

This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R ² was calculated for groups of interdependent input parameters. Partial R² was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R ² is an easy to obtain importance measure, also in the presence of interdependent input parameters.

Original language	English
Pages (from-to)	7611-7612
Number of pages	2
Journal	Procedia - Social and Behavioral Sciences
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/j.sbspro.2010.05.142
Publication status	Published - 1 Jan 2010
Event	6th International Conference on Sensitivity Analysis of Model Output, SAMO 2010 - Milan, Italy Duration: 19 Jul 2010 → 22 Jul 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

coefficient of determination
correlation
cost-effectiveness
dependency
sensitivity measure
uncertainty

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10.1016/j.sbspro.2010.05.142

Cite this

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title = "Cost-effectiveness of varicella and zoster vaccination in England\&Wales: Importance measures for correlated parameters",

abstract = "This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R 2 was calculated for groups of interdependent input parameters. Partial R2 was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R 2 is an easy to obtain importance measure, also in the presence of interdependent input parameters.",

keywords = "coefficient of determination, correlation, cost-effectiveness, dependency, sensitivity measure, uncertainty",

author = "J. Bilcke and \{Van Hoek\}, \{Albert Jan\} and N. Hens and M. Aerts and Edmunds, \{W. J.\} and P. Beutels",

note = "Copyright: Copyright 2010 Elsevier B.V., All rights reserved.; 6th International Conference on Sensitivity Analysis of Model Output, SAMO 2010 ; Conference date: 19-07-2010 Through 22-07-2010",

year = "2010",

month = jan,

day = "1",

doi = "10.1016/j.sbspro.2010.05.142",

language = "English",

volume = "2",

pages = "7611--7612",

journal = "Procedia - Social and Behavioral Sciences",

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TY - JOUR

T1 - Cost-effectiveness of varicella and zoster vaccination in England&Wales

T2 - 6th International Conference on Sensitivity Analysis of Model Output, SAMO 2010

AU - Bilcke, J.

AU - Van Hoek, Albert Jan

AU - Hens, N.

AU - Aerts, M.

AU - Edmunds, W. J.

AU - Beutels, P.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R 2 was calculated for groups of interdependent input parameters. Partial R2 was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R 2 is an easy to obtain importance measure, also in the presence of interdependent input parameters.

AB - This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R 2 was calculated for groups of interdependent input parameters. Partial R2 was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R 2 is an easy to obtain importance measure, also in the presence of interdependent input parameters.

KW - coefficient of determination

KW - correlation

KW - cost-effectiveness

KW - dependency

KW - sensitivity measure

KW - uncertainty

UR - https://www.scopus.com/pages/publications/77954970591

U2 - 10.1016/j.sbspro.2010.05.142

DO - 10.1016/j.sbspro.2010.05.142

M3 - Conference article

AN - SCOPUS:77954970591

SN - 1877-0428

VL - 2

SP - 7611

EP - 7612

JO - Procedia - Social and Behavioral Sciences

JF - Procedia - Social and Behavioral Sciences

IS - 6

Y2 - 19 July 2010 through 22 July 2010

ER -

Cost-effectiveness of varicella and zoster vaccination in England&Wales: Importance measures for correlated parameters

Abstract

UN SDGs

Keywords

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