Core pertussis transmission groups in England and Wales: A tale of two eras

Ana I. Bento*, Maria A. Riolo, Yoon Choi, Aaron A. King, Pejman Rohani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The recent resurgence of pertussis in England and Wales has been marked by infant deaths and rising cases in teens and adults. To understand which age cohorts are most responsible for these trends, we employed three separate statistical methods to analyze high-resolution pertussis reports from 1982 to 2012. The fine-grained nature of the time-series allowed us to describe the changes in age-specific incidence and contrast the transmission dynamics in the 1980s and during the resurgence era. Our results identified infants and school children younger than 10 years of age as a core group, prior to 2002: pertussis incidence in these populations was predictive of incidence in other age groups. After 2002, no core groups were identifiable. This conclusion is independent of methodology used. Because it is unlikely that the underlying contact patterns substantially changed over the study period, changes in predictability likely result from the introduction of more stringent diagnostics tests that may have inadvertently played a role in masking the relative contributions of core transmission groups.

Original languageEnglish
Pages (from-to)1160-1166
Number of pages7
JournalVaccine
Volume36
Issue number9
DOIs
Publication statusPublished - 21 Feb 2018

Bibliographical note

Funding Information:
This work was supported by a research grant from the National Institutes of Health (grant number 1R01AI101155 ) and by MIDAS, National Institute of General Medical Sciences (grant number U54-GM111274 ).

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Age-stratified incidence
  • Dynamical signature
  • Entropy
  • Relative risks transmission
  • Time-series data
  • Whooping cough

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