Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: A cohort study

T. Wingfield; P. MacPherson; P. Sodha; A. Tucker; J. Mithoo; S. B. Squire; Paul Cleary

doi:10.5588/ijtld.18.0467

Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: A cohort study

T. Wingfield^*, P. MacPherson, P. Sodha, A. Tucker, J. Mithoo, S. B. Squire, Paul Cleary

^*Corresponding author for this work

Field Epidemiology (North West)

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

OBJECTIVE : To investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England. DESIGN: This was a cohort study of all TB cases from NorthWest England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support). RESULTS : A total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smearpositive vs. smear-negative, OR 5.3, 95%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smearpositive vs. smear-negative, OR 5.3, 95%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95%CI 2.0- 25). CONCLUSIONS : The social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.

Original language	English
Pages (from-to)	337-343
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	23
Issue number	3
DOIs	https://doi.org/10.5588/ijtld.18.0467
Publication status	Published - 2019

Bibliographical note

Funding Information:
TW is supported by grants from the Wellcome Trust, London (209075/Z/17/Z); the Academy of Medical Sciences, London; the Liverpool Glasgow Wellcome Trust Centre for Global Health Research, Liverpool; the University of Liverpool, Liverpool, UK; the Swedish Health Research Council, Stockholm, Sweden; and the National Institute for Health Research (NIHR), London, UK. PM is funded by the Wellcome Trust (206575/Z/17/Z). JM is part-funded by The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care North West Coast, Liverpool, UK.

Publisher Copyright:
© 2019 The Union.

Keywords

Contact screening
Enhanced case management
Public health
Social and clinical complexity
TB
TB control
TB prevention

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.18.0467

Cite this

@article{d54db7daf06e45f9acfe493598664852,

title = "Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: A cohort study",

abstract = "OBJECTIVE : To investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England. DESIGN: This was a cohort study of all TB cases from NorthWest England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support). RESULTS : A total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smearpositive vs. smear-negative, OR 5.3, 95%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smearpositive vs. smear-negative, OR 5.3, 95%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95%CI 2.0- 25). CONCLUSIONS : The social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.",

keywords = "Contact screening, Enhanced case management, Public health, Social and clinical complexity, TB, TB control, TB prevention",

author = "T. Wingfield and P. MacPherson and P. Sodha and A. Tucker and J. Mithoo and Squire, {S. B.} and Paul Cleary",

note = "Funding Information: TW is supported by grants from the Wellcome Trust, London (209075/Z/17/Z); the Academy of Medical Sciences, London; the Liverpool Glasgow Wellcome Trust Centre for Global Health Research, Liverpool; the University of Liverpool, Liverpool, UK; the Swedish Health Research Council, Stockholm, Sweden; and the National Institute for Health Research (NIHR), London, UK. PM is funded by the Wellcome Trust (206575/Z/17/Z). JM is part-funded by The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care North West Coast, Liverpool, UK. Publisher Copyright: {\textcopyright} 2019 The Union.",

year = "2019",

doi = "10.5588/ijtld.18.0467",

language = "English",

volume = "23",

pages = "337--343",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union Against Tuberculosis and Lung Disease ",

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TY - JOUR

T1 - Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England

T2 - A cohort study

AU - Wingfield, T.

AU - MacPherson, P.

AU - Sodha, P.

AU - Tucker, A.

AU - Mithoo, J.

AU - Squire, S. B.

AU - Cleary, Paul

N1 - Funding Information: TW is supported by grants from the Wellcome Trust, London (209075/Z/17/Z); the Academy of Medical Sciences, London; the Liverpool Glasgow Wellcome Trust Centre for Global Health Research, Liverpool; the University of Liverpool, Liverpool, UK; the Swedish Health Research Council, Stockholm, Sweden; and the National Institute for Health Research (NIHR), London, UK. PM is funded by the Wellcome Trust (206575/Z/17/Z). JM is part-funded by The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care North West Coast, Liverpool, UK. Publisher Copyright: © 2019 The Union.

PY - 2019

Y1 - 2019

N2 - OBJECTIVE : To investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England. DESIGN: This was a cohort study of all TB cases from NorthWest England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support). RESULTS : A total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smearpositive vs. smear-negative, OR 5.3, 95%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smearpositive vs. smear-negative, OR 5.3, 95%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95%CI 2.0- 25). CONCLUSIONS : The social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.

AB - OBJECTIVE : To investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England. DESIGN: This was a cohort study of all TB cases from NorthWest England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support). RESULTS : A total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smearpositive vs. smear-negative, OR 5.3, 95%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smearpositive vs. smear-negative, OR 5.3, 95%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95%CI 2.0- 25). CONCLUSIONS : The social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.

KW - Contact screening

KW - Enhanced case management

KW - Public health

KW - Social and clinical complexity

KW - TB

KW - TB control

KW - TB prevention

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DO - 10.5588/ijtld.18.0467

M3 - Article

C2 - 30871665

AN - SCOPUS:85063007172

SN - 1027-3719

VL - 23

SP - 337

EP - 343

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 3

ER -

Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: A cohort study

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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