Consideration of hereditary effects in the radiological protection system: evolution and current status

A. Amrenova, E. Ainsbury, C. Baudin, A. Giussani, J. Lochard, W. Rühm, P. Scholz-Kreisel, K. Trott, L. Vaillant, R. Wakeford, F. Zölzer, D. Laurier*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Purpose: The purpose of this paper is to provide an overview of the methodology used to estimate radiation genetic risks and quantify the risk of hereditary effects as outlined in the ICRP Publication 103. It aims to highlight the historical background and development of the doubling dose method for estimating radiation-related genetic risks and its continued use in radiological protection frameworks. Results: This article emphasizes the complexity associated with quantifying the risk of hereditary effects caused by radiation exposure and highlights the need for further clarification and explanation of the calculation method. As scientific knowledge in radiation sciences and human genetics continues to advance in relation to a number of factors including stability of disease frequency, selection pressures, and epigenetic changes, the characterization and quantification of genetic effects still remains a major issue for the radiological protection system of the International Commission on Radiological Protection. Conclusion: Further research and advancements in this field are crucial for enhancing our understanding and addressing the complexities involved in assessing and managing the risks associated with hereditary effects of radiation.

Original languageEnglish
Pages (from-to)1240-1252
Number of pages13
JournalInternational Journal of Radiation Biology
Volume100
Issue number9
DOIs
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords

  • Ionizing radiation
  • doubling dose
  • hereditary effects
  • radiation genetic risk estimation
  • radiological protection

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