Complete genome sequence of Ikoma lyssavirus

Denise A. Marston, Richard J. Ellis, Daniel L. Horton, Ivan V. Kuzmin, Emma L. Wise, Lorraine M. McElhinney, Ashley C. Banyard, Chanasa Ngeleja, Julius Keyyu, Sarah Cleaveland, Tiziana Lembo, Charles E. Rupprecht, Anthony R. Fooks*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

15 Citations (Scopus)

Abstract

Lyssaviruses (family Rhabdoviridae) constitute one of the most important groups of viral zoonoses globally. All lyssaviruses cause the disease rabies, an acute progressive encephalitis for which, once symptoms occur, there is no effective cure. Currently available vaccines are highly protective against the predominantly circulating lyssavirus species. Using next-generation sequencing technologies, we have obtained the whole-genome sequence for a novel lyssavirus, Ikoma lyssavirus (IKOV), isolated from an African civet in Tanzania displaying clinical signs of rabies. Genetically, this virus is the most divergent within the genus Lyssavirus. Characterization of the genome will help to improve our understanding of lyssavirus diversity and enable investigation into vaccine-induced immunity and protection.

Original languageEnglish
Pages (from-to)10242-10243
Number of pages2
JournalJournal of Virology
Volume86
Issue number18
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

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