Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa

Jonathan D. Edgeworth; Domenico Merante; Sanjay Patel; Christopher Young; Paul Jones; Seema Vithlani; Duncan Wyncoll; Peter Roberts; Andrew Jones; Tsutae Den Nagata; Mari Ariyasu; David Livermore; Richard Beale

doi:10.1093/cid/ciy963

Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa

Jonathan D. Edgeworth^*
, Domenico Merante
, Sanjay Patel
, Christopher Young
, Paul Jones
, Seema Vithlani
, Duncan Wyncoll
, Peter Roberts
, Andrew Jones
, Tsutae Den Nagata
, Mari Ariyasu
, David Livermore
, Richard Beale

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.

Original language	English
Pages (from-to)	1932-1934
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	68
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciy963
Publication status	Published - 17 May 2019

Bibliographical note

Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cefiderocol
Pseudomonas aeruginosa
drug resistance
endocarditis
microbial

Access to Document

10.1093/cid/ciy963

Cite this

Edgeworth, J. D., Merante, D., Patel, S., Young, C., Jones, P., Vithlani, S., Wyncoll, D., Roberts, P., Jones, A., Den Nagata, T., Ariyasu, M., Livermore, D., & Beale, R. (2019). Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa. Clinical Infectious Diseases, 68(11), 1932-1934. https://doi.org/10.1093/cid/ciy963

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abstract = "Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.",

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Edgeworth, JD, Merante, D, Patel, S, Young, C, Jones, P, Vithlani, S, Wyncoll, D, Roberts, P, Jones, A, Den Nagata, T, Ariyasu, M, Livermore, D & Beale, R 2019, 'Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa', Clinical Infectious Diseases, vol. 68, no. 11, pp. 1932-1934. https://doi.org/10.1093/cid/ciy963

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AU - Edgeworth, Jonathan D.

AU - Merante, Domenico

AU - Patel, Sanjay

AU - Young, Christopher

AU - Jones, Paul

AU - Vithlani, Seema

AU - Wyncoll, Duncan

AU - Roberts, Peter

AU - Jones, Andrew

AU - Den Nagata, Tsutae

AU - Ariyasu, Mari

AU - Livermore, David

AU - Beale, Richard

PY - 2019/5/17

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N2 - Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.

AB - Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.

KW - Cefiderocol

KW - Pseudomonas aeruginosa

KW - drug resistance

KW - endocarditis

KW - microbial

UR - https://www.scopus.com/pages/publications/85066832165

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VL - 68

SP - 1932

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 11

ER -

Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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