Comparison of predicted with observed biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans

Alan Hodgson; A. L. Shutt; George Etherington; S. A. Hodgson; E. Rance; G. N. Stradling; M. J. Youngman; A. Ziesenis; W. G. Kreyling

doi:10.1093/oxfordjournals.rpd.a006328

Comparison of predicted with observed biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans

Alan Hodgson^*
, A. L. Shutt
, George Etherington
, S. A. Hodgson
, E. Rance
, G. N. Stradling
, M. J. Youngman
, A. Ziesenis
, W. G. Kreyling

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The absorption kinetics to blood of plutonium and gadolinium after inhalation as nitrate and oxide in humans and animals has been studied. For each material, values describing the time dependence of absorption were derived from the studies in animals and used with the ICRP human respiratory tract model to predict lung retention and cumulative amounts to blood for the volunteers inhaling the same materials. Comparison with the observed behaviour in the volunteers suggests that absorption of plutonium and gadolinium is reasonably species independent, and that data obtained from animal studies can be used to assess their biokinetic behaviour in humans.

Original language	English
Pages (from-to)	91-94
Number of pages	4
Journal	Radiation Protection Dosimetry
Volume	105
Issue number	1-4
DOIs	https://doi.org/10.1093/oxfordjournals.rpd.a006328
Publication status	Published - 2003

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10.1093/oxfordjournals.rpd.a006328

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title = "Comparison of predicted with observed biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans",

abstract = "The absorption kinetics to blood of plutonium and gadolinium after inhalation as nitrate and oxide in humans and animals has been studied. For each material, values describing the time dependence of absorption were derived from the studies in animals and used with the ICRP human respiratory tract model to predict lung retention and cumulative amounts to blood for the volunteers inhaling the same materials. Comparison with the observed behaviour in the volunteers suggests that absorption of plutonium and gadolinium is reasonably species independent, and that data obtained from animal studies can be used to assess their biokinetic behaviour in humans.",

author = "Alan Hodgson and Shutt, \{A. L.\} and George Etherington and Hodgson, \{S. A.\} and E. Rance and Stradling, \{G. N.\} and Youngman, \{M. J.\} and A. Ziesenis and Kreyling, \{W. G.\}",

year = "2003",

doi = "10.1093/oxfordjournals.rpd.a006328",

language = "English",

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T1 - Comparison of predicted with observed biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans

AU - Hodgson, Alan

AU - Shutt, A. L.

AU - Etherington, George

AU - Hodgson, S. A.

AU - Rance, E.

AU - Stradling, G. N.

AU - Youngman, M. J.

AU - Ziesenis, A.

AU - Kreyling, W. G.

PY - 2003

Y1 - 2003

N2 - The absorption kinetics to blood of plutonium and gadolinium after inhalation as nitrate and oxide in humans and animals has been studied. For each material, values describing the time dependence of absorption were derived from the studies in animals and used with the ICRP human respiratory tract model to predict lung retention and cumulative amounts to blood for the volunteers inhaling the same materials. Comparison with the observed behaviour in the volunteers suggests that absorption of plutonium and gadolinium is reasonably species independent, and that data obtained from animal studies can be used to assess their biokinetic behaviour in humans.

AB - The absorption kinetics to blood of plutonium and gadolinium after inhalation as nitrate and oxide in humans and animals has been studied. For each material, values describing the time dependence of absorption were derived from the studies in animals and used with the ICRP human respiratory tract model to predict lung retention and cumulative amounts to blood for the volunteers inhaling the same materials. Comparison with the observed behaviour in the volunteers suggests that absorption of plutonium and gadolinium is reasonably species independent, and that data obtained from animal studies can be used to assess their biokinetic behaviour in humans.

UR - https://www.scopus.com/pages/publications/0141633009

U2 - 10.1093/oxfordjournals.rpd.a006328

DO - 10.1093/oxfordjournals.rpd.a006328

M3 - Article

C2 - 14526934

AN - SCOPUS:0141633009

SN - 0144-8420

VL - 105

SP - 91

EP - 94

JO - Radiation Protection Dosimetry

JF - Radiation Protection Dosimetry

IS - 1-4

ER -

Comparison of predicted with observed biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans

Abstract

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