Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program

Shinsuke Miyano; Emilia Vynnycky; Chansay Pattamavone; Yasunori Ichimura; Yoshio Mori; Phonethipsavanh Nouanthong; Kongxay Phounphenghack; Chankham Tengbriacheu; Bouaphne Khamphaphongphane; Lauren Franzel; Tae Un Yang; Hendrikus Raaijimarkers; Kenichi Komada; Tomomi Ota; Masafumi Funato; Makoto Takeda; Masahiko Hachiya

doi:10.1016/j.ijid.2023.01.044

Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program

Shinsuke Miyano^*
, Emilia Vynnycky
, Chansay Pattamavone
, Yasunori Ichimura
, Yoshio Mori
, Phonethipsavanh Nouanthong
, Kongxay Phounphenghack
, Chankham Tengbriacheu
, Bouaphne Khamphaphongphane
, Lauren Franzel
, Tae Un Yang
, Hendrikus Raaijimarkers
, Kenichi Komada
, Tomomi Ota
, Masafumi Funato
, Makoto Takeda
, Masahiko Hachiya

^*Corresponding author for this work

Modelling Economics Unit

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

12 Downloads (Pure)

Abstract

Objectives: We evaluated the effectiveness of the Lao People's Democratic Republic's measles-rubella immunization program using the seroprevalence from two cross-sectional surveys.

Methods: The nationwide surveys occurred in 2014 and 2019 using a multistage cluster sampling, both requiring samples from 2184 individuals from 52 randomly selected villages. Immunoglobulin G titers, measured using enzyme-linked immunosorbent assay, were considered positive at ≥120 mIU/ml (measles) and ≥10 IU/ml (rubella). We calculated the vaccination-related reduction in the force of rubella infection and the number of congenital rubella syndrome cases averted in 2019.

Results: We collected 2135 (women: 55.2%, mean age: 23.2 years) and 2001 (52.7%, 23.1 years) samples in 2014 and 2019, respectively. During 2014-2019, immunoglobulin G prevalence increased from 83.9% (95% confidence interval [CI]: 83.8-84.0) to 98.3% (97.7-98.8) for measles and from 75.4% (75.3-75.5) to 87.8% (86.4-89.2) for rubella. The most plausible reduction in the average force of rubella infection was 100% (95% CI: 28-100) since vaccination started, averting 78 (95% CI: 42-128) congenital rubella syndrome cases in 2019.

Conclusion: This is the first population-based study for measles and rubella at two different time points in developing countries. Measles and rubella seroprevalence increased significantly during 2014-2019, greatly exceeding the immunity thresholds for their elimination.

Original language	English
Pages (from-to)	70-77
Number of pages	8
Journal	International Journal of Infectious Diseases
Volume	129
Early online date	18 Feb 2023
DOIs	https://doi.org/10.1016/j.ijid.2023.01.044
Publication status	Published - Apr 2023

Bibliographical note

Funding Information: This work was supported by the NCGM Intramural Research Fund (25-8, 19A01 and 22A01), Japan and the Grant for the National Immunization Program, Lao PDR (FY2019). However, the funders had no role in the study design, data collection, data analysis, data interpretation, or writing of the manuscript.

Open Access: This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/)

Publisher Copyright: © 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Citation: Shinsuke Miyano, Emilia Vynnycky, Chansay Pattamavone, Yasunori Ichimura, Yoshio Mori, Phonethipsavanh Nouanthong, Kongxay Phounphenghack, Chankham Tengbriacheu, Bouaphne Khamphaphongphane, Lauren Franzel, Tae Un Yang, Hendrikus Raaijimarkers, Kenichi Komada, Tomomi Ota, Masafumi Funato, Makoto Takeda, Masahiko Hachiya, Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program, International Journal of Infectious Diseases, Volume 129, 2023, Pages 70-77, ISSN 1201-9712, https://doi.org/10.1016/j.ijid.2023.01.044.
(https://www.sciencedirect.com/science/article/pii/S1201971223000450)

DOI: https://doi.org/10.1016/j.ijid.2023.01.044.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Elimination
Mathematical modeling
Measles
Population-based
Rubella
Seroprevalence survey

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10.1016/j.ijid.2023.01.044Licence: CC BY-NC-ND

Miyano2023ComparisonOfPopulationBasedMeaslesRubellaImmunoglobulinGAntibodyPrevalenceBetween2014And2019IntJInfectDisFinal published version, 1.17 MBLicence: CC BY-NC-ND

Cite this

Miyano, S., Vynnycky, E., Pattamavone, C., Ichimura, Y., Mori, Y., Nouanthong, P., Phounphenghack, K., Tengbriacheu, C., Khamphaphongphane, B., Franzel, L., Yang, T. U., Raaijimarkers, H., Komada, K., Ota, T., Funato, M., Takeda, M., & Hachiya, M. (2023). Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program. International Journal of Infectious Diseases, 129, 70-77. https://doi.org/10.1016/j.ijid.2023.01.044

@article{8fa6f247489b4de9a2e0091dfa1e3b78,

title = "Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program",

abstract = "Objectives: We evaluated the effectiveness of the Lao People's Democratic Republic's measles-rubella immunization program using the seroprevalence from two cross-sectional surveys. Methods: The nationwide surveys occurred in 2014 and 2019 using a multistage cluster sampling, both requiring samples from 2184 individuals from 52 randomly selected villages. Immunoglobulin G titers, measured using enzyme-linked immunosorbent assay, were considered positive at ≥120 mIU/ml (measles) and ≥10 IU/ml (rubella). We calculated the vaccination-related reduction in the force of rubella infection and the number of congenital rubella syndrome cases averted in 2019. Results: We collected 2135 (women: 55.2\%, mean age: 23.2 years) and 2001 (52.7\%, 23.1 years) samples in 2014 and 2019, respectively. During 2014-2019, immunoglobulin G prevalence increased from 83.9\% (95\% confidence interval [CI]: 83.8-84.0) to 98.3\% (97.7-98.8) for measles and from 75.4\% (75.3-75.5) to 87.8\% (86.4-89.2) for rubella. The most plausible reduction in the average force of rubella infection was 100\% (95\% CI: 28-100) since vaccination started, averting 78 (95\% CI: 42-128) congenital rubella syndrome cases in 2019. Conclusion: This is the first population-based study for measles and rubella at two different time points in developing countries. Measles and rubella seroprevalence increased significantly during 2014-2019, greatly exceeding the immunity thresholds for their elimination.",

keywords = "Elimination, Mathematical modeling, Measles, Population-based, Rubella, Seroprevalence survey",

author = "Shinsuke Miyano and Emilia Vynnycky and Chansay Pattamavone and Yasunori Ichimura and Yoshio Mori and Phonethipsavanh Nouanthong and Kongxay Phounphenghack and Chankham Tengbriacheu and Bouaphne Khamphaphongphane and Lauren Franzel and Yang, \{Tae Un\} and Hendrikus Raaijimarkers and Kenichi Komada and Tomomi Ota and Masafumi Funato and Makoto Takeda and Masahiko Hachiya",

note = "Funding Information: This work was supported by the NCGM Intramural Research Fund (25-8, 19A01 and 22A01), Japan and the Grant for the National Immunization Program, Lao PDR (FY2019). However, the funders had no role in the study design, data collection, data analysis, data interpretation, or writing of the manuscript. Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. Citation: Shinsuke Miyano, Emilia Vynnycky, Chansay Pattamavone, Yasunori Ichimura, Yoshio Mori, Phonethipsavanh Nouanthong, Kongxay Phounphenghack, Chankham Tengbriacheu, Bouaphne Khamphaphongphane, Lauren Franzel, Tae Un Yang, Hendrikus Raaijimarkers, Kenichi Komada, Tomomi Ota, Masafumi Funato, Makoto Takeda, Masahiko Hachiya, Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program, International Journal of Infectious Diseases, Volume 129, 2023, Pages 70-77, ISSN 1201-9712, https://doi.org/10.1016/j.ijid.2023.01.044. (https://www.sciencedirect.com/science/article/pii/S1201971223000450) DOI: https://doi.org/10.1016/j.ijid.2023.01.044.",

year = "2023",

month = apr,

doi = "10.1016/j.ijid.2023.01.044",

language = "English",

volume = "129",

pages = "70--77",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier B.V.",

}

Miyano, S, Vynnycky, E, Pattamavone, C, Ichimura, Y, Mori, Y, Nouanthong, P, Phounphenghack, K, Tengbriacheu, C, Khamphaphongphane, B, Franzel, L, Yang, TU, Raaijimarkers, H, Komada, K, Ota, T, Funato, M, Takeda, M & Hachiya, M 2023, 'Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program', International Journal of Infectious Diseases, vol. 129, pp. 70-77. https://doi.org/10.1016/j.ijid.2023.01.044

Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program. / Miyano, Shinsuke; Vynnycky, Emilia; Pattamavone, Chansay et al.
In: International Journal of Infectious Diseases, Vol. 129, 04.2023, p. 70-77.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic

T2 - Impacts of the national immunization program

AU - Miyano, Shinsuke

AU - Vynnycky, Emilia

AU - Pattamavone, Chansay

AU - Ichimura, Yasunori

AU - Mori, Yoshio

AU - Nouanthong, Phonethipsavanh

AU - Phounphenghack, Kongxay

AU - Tengbriacheu, Chankham

AU - Khamphaphongphane, Bouaphne

AU - Franzel, Lauren

AU - Yang, Tae Un

AU - Raaijimarkers, Hendrikus

AU - Komada, Kenichi

AU - Ota, Tomomi

AU - Funato, Masafumi

AU - Takeda, Makoto

AU - Hachiya, Masahiko

N1 - Funding Information: This work was supported by the NCGM Intramural Research Fund (25-8, 19A01 and 22A01), Japan and the Grant for the National Immunization Program, Lao PDR (FY2019). However, the funders had no role in the study design, data collection, data analysis, data interpretation, or writing of the manuscript. Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Publisher Copyright: © 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. Citation: Shinsuke Miyano, Emilia Vynnycky, Chansay Pattamavone, Yasunori Ichimura, Yoshio Mori, Phonethipsavanh Nouanthong, Kongxay Phounphenghack, Chankham Tengbriacheu, Bouaphne Khamphaphongphane, Lauren Franzel, Tae Un Yang, Hendrikus Raaijimarkers, Kenichi Komada, Tomomi Ota, Masafumi Funato, Makoto Takeda, Masahiko Hachiya, Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program, International Journal of Infectious Diseases, Volume 129, 2023, Pages 70-77, ISSN 1201-9712, https://doi.org/10.1016/j.ijid.2023.01.044. (https://www.sciencedirect.com/science/article/pii/S1201971223000450) DOI: https://doi.org/10.1016/j.ijid.2023.01.044.

PY - 2023/4

Y1 - 2023/4

N2 - Objectives: We evaluated the effectiveness of the Lao People's Democratic Republic's measles-rubella immunization program using the seroprevalence from two cross-sectional surveys. Methods: The nationwide surveys occurred in 2014 and 2019 using a multistage cluster sampling, both requiring samples from 2184 individuals from 52 randomly selected villages. Immunoglobulin G titers, measured using enzyme-linked immunosorbent assay, were considered positive at ≥120 mIU/ml (measles) and ≥10 IU/ml (rubella). We calculated the vaccination-related reduction in the force of rubella infection and the number of congenital rubella syndrome cases averted in 2019. Results: We collected 2135 (women: 55.2%, mean age: 23.2 years) and 2001 (52.7%, 23.1 years) samples in 2014 and 2019, respectively. During 2014-2019, immunoglobulin G prevalence increased from 83.9% (95% confidence interval [CI]: 83.8-84.0) to 98.3% (97.7-98.8) for measles and from 75.4% (75.3-75.5) to 87.8% (86.4-89.2) for rubella. The most plausible reduction in the average force of rubella infection was 100% (95% CI: 28-100) since vaccination started, averting 78 (95% CI: 42-128) congenital rubella syndrome cases in 2019. Conclusion: This is the first population-based study for measles and rubella at two different time points in developing countries. Measles and rubella seroprevalence increased significantly during 2014-2019, greatly exceeding the immunity thresholds for their elimination.

AB - Objectives: We evaluated the effectiveness of the Lao People's Democratic Republic's measles-rubella immunization program using the seroprevalence from two cross-sectional surveys. Methods: The nationwide surveys occurred in 2014 and 2019 using a multistage cluster sampling, both requiring samples from 2184 individuals from 52 randomly selected villages. Immunoglobulin G titers, measured using enzyme-linked immunosorbent assay, were considered positive at ≥120 mIU/ml (measles) and ≥10 IU/ml (rubella). We calculated the vaccination-related reduction in the force of rubella infection and the number of congenital rubella syndrome cases averted in 2019. Results: We collected 2135 (women: 55.2%, mean age: 23.2 years) and 2001 (52.7%, 23.1 years) samples in 2014 and 2019, respectively. During 2014-2019, immunoglobulin G prevalence increased from 83.9% (95% confidence interval [CI]: 83.8-84.0) to 98.3% (97.7-98.8) for measles and from 75.4% (75.3-75.5) to 87.8% (86.4-89.2) for rubella. The most plausible reduction in the average force of rubella infection was 100% (95% CI: 28-100) since vaccination started, averting 78 (95% CI: 42-128) congenital rubella syndrome cases in 2019. Conclusion: This is the first population-based study for measles and rubella at two different time points in developing countries. Measles and rubella seroprevalence increased significantly during 2014-2019, greatly exceeding the immunity thresholds for their elimination.

KW - Elimination

KW - Mathematical modeling

KW - Measles

KW - Population-based

KW - Rubella

KW - Seroprevalence survey

UR - https://www.scopus.com/pages/publications/85148379511

U2 - 10.1016/j.ijid.2023.01.044

DO - 10.1016/j.ijid.2023.01.044

M3 - Article

C2 - 36758852

AN - SCOPUS:85148379511

SN - 1201-9712

VL - 129

SP - 70

EP - 77

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Miyano S, Vynnycky E, Pattamavone C, Ichimura Y, Mori Y, Nouanthong P et al. Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program. International Journal of Infectious Diseases. 2023 Apr;129:70-77. Epub 2023 Feb 18. doi: 10.1016/j.ijid.2023.01.044

Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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