Comparison of Age-Stratified Seroprevalence of Antibodies against Norovirus GII in India and the United Kingdom

Vipin Kumar Menon; Santosh George; Farah Aladin; Sameena Nawaz; Rajiv Sarkar; Ben Lopman; James Gray; Miren Iturriza-Go'Mara; Gagandeep Kang

doi:10.1371/journal.pone.0056239

Comparison of Age-Stratified Seroprevalence of Antibodies against Norovirus GII in India and the United Kingdom

Vipin Kumar Menon, Santosh George, Farah Aladin, Sameena Nawaz, Rajiv Sarkar, Ben Lopman, James Gray, Miren Iturriza-Go'Mara, Gagandeep Kang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Noroviruses are a common cause of gastroenteritis worldwide, but outbreaks appear to be more common in industrialized countries than in developing countries, possibly reflecting differences in exposure and immunity. In this study, age-stratified sera from India and UK populations were analysed for the presence of norovirus-genogroup II specific IgG by a time resolved immunofluorescence assay and relative levels of antibodies in the two populations were compared. Antibody levels were higher among all age groups in India than in UK and increased with age in India, whereas in the UK, levels of antibody decreased in adulthood. These results indicate different patterns of exposure to noroviruses in the two countries.

Original language	English
Article number	e56239
Journal	PLoS ONE
Volume	8
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0056239
Publication status	Published - 21 Feb 2013

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AU - Sarkar, Rajiv

AU - Lopman, Ben

AU - Gray, James

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Comparison of Age-Stratified Seroprevalence of Antibodies against Norovirus GII in India and the United Kingdom

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