Comparison between biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans and animals

N. Stradling; George Etherington; Alan Hodgson; Michael Bailey; S. Hodgson; P. Pellow; A. L. Shutt; A. Birchall; E. Rance; D. Newton; K. Fifield

doi:10.1023/A:1015722507393

Comparison between biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans and animals

N. Stradling^*, George Etherington, Alan Hodgson, Michael Bailey, S. Hodgson, P. Pellow, A. L. Shutt, A. Birchall, E. Rance, D. Newton, K. Fifield

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Due to the paucity of human data after inhalation of different chemical forms of radionuclides, the implications for human exposure are often based on animal studies. This paper describes biokinetic studies of plutonium nitrate and gadolinium oxide in human volunteers and rats. The results, together with information from other studies with radionuclides, suggests that animal studies can be used with advantage for assessing the biokinetic behavior in humans, and for providing guidance on the assessment of intake and optimal monitoring regimens.

Original language	English
Pages (from-to)	315-325
Number of pages	11
Journal	Journal of Radioanalytical and Nuclear Chemistry Articles
Volume	252
Issue number	2
DOIs	https://doi.org/10.1023/A:1015722507393
Publication status	Published - 2002

Bibliographical note

Funding Information:
This paper is based on research carried out under the auspices of the Nuclear Fission Safety Programme of the European Commission, Fourth Framework Programme, Contract F14P-CT95-0026. We are also indebted to the Nuclear Installations Inspectorate, Health and Safety Executive, UK, for their financial support for the human volunteer studies. Contract NUC 56/383/1P1E2.

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Stradling, N., Etherington, G., Hodgson, A., Bailey, M., Hodgson, S., Pellow, P., Shutt, A. L., Birchall, A., Rance, E., Newton, D., & Fifield, K. (2002). Comparison between biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans and animals. Journal of Radioanalytical and Nuclear Chemistry Articles, 252(2), 315-325. https://doi.org/10.1023/A:1015722507393

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title = "Comparison between biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans and animals",

abstract = "Due to the paucity of human data after inhalation of different chemical forms of radionuclides, the implications for human exposure are often based on animal studies. This paper describes biokinetic studies of plutonium nitrate and gadolinium oxide in human volunteers and rats. The results, together with information from other studies with radionuclides, suggests that animal studies can be used with advantage for assessing the biokinetic behavior in humans, and for providing guidance on the assessment of intake and optimal monitoring regimens.",

author = "N. Stradling and George Etherington and Alan Hodgson and Michael Bailey and S. Hodgson and P. Pellow and Shutt, {A. L.} and A. Birchall and E. Rance and D. Newton and K. Fifield",

note = "Funding Information: This paper is based on research carried out under the auspices of the Nuclear Fission Safety Programme of the European Commission, Fourth Framework Programme, Contract F14P-CT95-0026. We are also indebted to the Nuclear Installations Inspectorate, Health and Safety Executive, UK, for their financial support for the human volunteer studies. Contract NUC 56/383/1P1E2.",

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doi = "10.1023/A:1015722507393",

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Stradling, N, Etherington, G, Hodgson, A, Bailey, M, Hodgson, S, Pellow, P, Shutt, AL, Birchall, A, Rance, E, Newton, D & Fifield, K 2002, 'Comparison between biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans and animals', Journal of Radioanalytical and Nuclear Chemistry Articles, vol. 252, no. 2, pp. 315-325. https://doi.org/10.1023/A:1015722507393

TY - JOUR

T1 - Comparison between biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans and animals

AU - Stradling, N.

AU - Etherington, George

AU - Hodgson, Alan

AU - Bailey, Michael

AU - Hodgson, S.

AU - Pellow, P.

AU - Shutt, A. L.

AU - Birchall, A.

AU - Rance, E.

AU - Newton, D.

AU - Fifield, K.

N1 - Funding Information: This paper is based on research carried out under the auspices of the Nuclear Fission Safety Programme of the European Commission, Fourth Framework Programme, Contract F14P-CT95-0026. We are also indebted to the Nuclear Installations Inspectorate, Health and Safety Executive, UK, for their financial support for the human volunteer studies. Contract NUC 56/383/1P1E2.

PY - 2002

Y1 - 2002

N2 - Due to the paucity of human data after inhalation of different chemical forms of radionuclides, the implications for human exposure are often based on animal studies. This paper describes biokinetic studies of plutonium nitrate and gadolinium oxide in human volunteers and rats. The results, together with information from other studies with radionuclides, suggests that animal studies can be used with advantage for assessing the biokinetic behavior in humans, and for providing guidance on the assessment of intake and optimal monitoring regimens.

AB - Due to the paucity of human data after inhalation of different chemical forms of radionuclides, the implications for human exposure are often based on animal studies. This paper describes biokinetic studies of plutonium nitrate and gadolinium oxide in human volunteers and rats. The results, together with information from other studies with radionuclides, suggests that animal studies can be used with advantage for assessing the biokinetic behavior in humans, and for providing guidance on the assessment of intake and optimal monitoring regimens.

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U2 - 10.1023/A:1015722507393

DO - 10.1023/A:1015722507393

M3 - Article

AN - SCOPUS:0036098227

SN - 0236-5731

VL - 252

SP - 315

EP - 325

JO - Journal of Radioanalytical and Nuclear Chemistry Articles

JF - Journal of Radioanalytical and Nuclear Chemistry Articles

IS - 2

ER -

Comparison between biokinetics of inhaled plutonium nitrate and gadolinium oxide in humans and animals

Abstract

Bibliographical note

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