TY - JOUR
T1 - Comparative pathology of experimental pulmonary tuberculosis in animal models
AU - Hunter, Laura
AU - Ruedas-Torres, Inés
AU - Agulló-Ros, Irene
AU - Rayner, Emma
AU - Salguero, Francisco J.
N1 - Publisher Copyright:
Copyright © 2023 Hunter, Ruedas-Torres, Agulló-Ros, Rayner and Salguero.
PY - 2023
Y1 - 2023
N2 - Research in human tuberculosis (TB) is limited by the availability of human tissues from patients, which is often altered by therapy and treatment. Thus, the use of animal models is a key tool in increasing our understanding of the pathogenesis, disease progression and preclinical evaluation of new therapies and vaccines. The granuloma is the hallmark lesion of pulmonary tuberculosis, regardless of the species or animal model used. Although animal models may not fully replicate all the histopathological characteristics observed in natural, human TB disease, each one brings its own attributes which enable researchers to answer specific questions regarding TB immunopathogenesis. This review delves into the pulmonary pathology induced by Mycobacterium tuberculosis complex (MTBC) bacteria in different animal models (non-human primates, rodents, guinea pigs, rabbits, cattle, goats, and others) and compares how they relate to the pulmonary disease described in humans. Although the described models have demonstrated some histopathological features in common with human pulmonary TB, these data should be considered carefully in the context of this disease. Further research is necessary to establish the most appropriate model for the study of TB, and to carry out a standard characterisation and score of pulmonary lesions.
AB - Research in human tuberculosis (TB) is limited by the availability of human tissues from patients, which is often altered by therapy and treatment. Thus, the use of animal models is a key tool in increasing our understanding of the pathogenesis, disease progression and preclinical evaluation of new therapies and vaccines. The granuloma is the hallmark lesion of pulmonary tuberculosis, regardless of the species or animal model used. Although animal models may not fully replicate all the histopathological characteristics observed in natural, human TB disease, each one brings its own attributes which enable researchers to answer specific questions regarding TB immunopathogenesis. This review delves into the pulmonary pathology induced by Mycobacterium tuberculosis complex (MTBC) bacteria in different animal models (non-human primates, rodents, guinea pigs, rabbits, cattle, goats, and others) and compares how they relate to the pulmonary disease described in humans. Although the described models have demonstrated some histopathological features in common with human pulmonary TB, these data should be considered carefully in the context of this disease. Further research is necessary to establish the most appropriate model for the study of TB, and to carry out a standard characterisation and score of pulmonary lesions.
KW - animal models
KW - granuloma
KW - lung
KW - mycobacteria
KW - pathology
KW - tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85175072431&partnerID=8YFLogxK
U2 - 10.3389/fvets.2023.1264833
DO - 10.3389/fvets.2023.1264833
M3 - Review article
AN - SCOPUS:85175072431
SN - 2297-1769
VL - 10
JO - Frontiers in Veterinary Science
JF - Frontiers in Veterinary Science
M1 - 1264833
ER -