Comparative Effectiveness of Stereotactic Electroencephalography Versus Subdural Grids in Epilepsy Surgery

Lara Jehi*, Marcia Morita-Sherman, Thomas E. Love, Fabrice Bartolomei, William Bingaman, Kees Braun, Robyn M. Busch, John Duncan, Walter J. Hader, Guoming Luan, John D. Rolston, Stephan Schuele, Laura Tassi, Sumeet Vadera, Shehryar Sheikh, Imad Najm, Amir Arain, Justin Bingaman, Beate Diehl, Jane de TisiMatea Rados, Pieter Van Eijsden, Sandra Wahby, Xiongfei Wang, Samuel Wiebe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim was to compare the outcomes of subdural electrode (SDE) implantations versus stereotactic electroencephalography (SEEG), the 2 predominant methods of intracranial electroencephalography (iEEG) performed in difficult-to-localize drug-resistant focal epilepsy. Methods: The Surgical Therapies Commission of the International League Against Epilepsy created an international registry of iEEG patients implanted between 2005 and 2019 with ≥1 year of follow-up. We used propensity score matching to control exposure selection bias and generate comparable cohorts. Study endpoints were: (1) likelihood of resection after iEEG; (2) seizure freedom at last follow-up; and (3) complications (composite of postoperative infection, symptomatic intracranial hemorrhage, or permanent neurological deficit). Results: Ten study sites from 7 countries and 3 continents contributed 2,012 patients, including 1,468 (73%) eligible for analysis (526 SDE and 942 SEEG), of whom 988 (67%) underwent subsequent resection. Propensity score matching improved covariate balance between exposure groups for all analyses. Propensity-matched patients who underwent SDE had higher odds of subsequent resective surgery (odds ratio [OR] = 1.4, 95% confidence interval [CI] 1.05, 1.84) and higher odds of complications (OR = 2.24, 95% CI 1.34, 3.74; unadjusted: 9.6% after SDE vs 3.3% after SEEG). Odds of seizure freedom in propensity-matched resected patients were 1.66 times higher (95% CI 1.21, 2.26) for SEEG compared with SDE (unadjusted: 55% seizure free after SEEG-guided resections vs 41% after SDE). Interpretation: In comparison to SEEG, SDE evaluations are more likely to lead to brain surgery in patients with drug-resistant epilepsy but have more surgical complications and lower probability of seizure freedom. This comparative-effectiveness study provides the highest feasible evidence level to guide decisions on iEEG. ANN NEUROL 2021.

Original languageEnglish
JournalAnnals of Neurology
DOIs
Publication statusAccepted/In press - 2021
Externally publishedYes

Bibliographical note

Funding Information:
This project received funding from the International League Against Epilepsy (funding of statistical analysis) and National Institute of Neurological Disorders and Stroke (number R01NS097719; effort for data collection in Cleveland Clinic). Some of the data reported in this paper were collected as part of a project undertaken by the International League against Epilepsy (ILAE), and some of the authors are experts selected by the ILAE. Opinions expressed by the authors, however, do not necessarily represent the policy or position of the ILAE.

Publisher Copyright:
© 2021 American Neurological Association.

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