Community-associated meticillin-resistant Staphylococcus aureus: epidemiology, microbiology and clinical impact in East Yorkshire, UK

J. W.T. Elston*, J. Meigh, Angela Kearns, N. Jordan-Owers, A. Newton, R. E. Meigh, G. Barlow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing worldwide. Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yorkshire and describe their epidemiology, microbiology and clinical impact. Although CA-MRSA was most often associated with uncomplicated skin and soft tissue infections or asymptomatic colonisation, serious infection and fatalities were documented. Community-based transmission was noted in two separate households. We highlight limitations to existing definitions and propose debate to further define CA-MRSA and allow further study of its epidemiology and clinical impact in the UK.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalJournal of Hospital Infection
Volume72
Issue number4
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Clinical impact
  • Community-associated
  • Epidemiology
  • Meticillin-resistant Staphylococcus aureus
  • Panton-Valentine leucocidin

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