TY - JOUR
T1 - Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo hemorrhagic fever virus
AU - Chamberlain, John
AU - Cook, Nicola
AU - Lloyd, Graham
AU - Mioulet, Valerie
AU - Tolley, Howard
AU - Hewson, Roger
PY - 2005/12
Y1 - 2005/12
N2 - The genus Nairovirus of the family Bunyaviridae includes the Crimean-Congo haemorrhagic fever (CCHF) species group. The species is predominated by the hazard-group 4 pathogens, from which the name and majority of strain entries are derived. Additionally, the species embraces hazard-group 2 viruses that are classified as members by antigenic cross-reactivity. CCHF viruses have a tripartite RNA genome consisting of large (L), medium (M) and small (S) segments. Here, the sequence characterization of previously undescribed L and S segments from novel strains originating in the Middle East and Africa is reported. Further scrutiny of this data with phylogenetic tools, in the context of other publicly available sequence information, reveals analogous grouping patterns between the L and S segments. These groups correlate with the geographical distribution of strain isolation and indicate that the L and S segments of CCHF viruses have evolved together.
AB - The genus Nairovirus of the family Bunyaviridae includes the Crimean-Congo haemorrhagic fever (CCHF) species group. The species is predominated by the hazard-group 4 pathogens, from which the name and majority of strain entries are derived. Additionally, the species embraces hazard-group 2 viruses that are classified as members by antigenic cross-reactivity. CCHF viruses have a tripartite RNA genome consisting of large (L), medium (M) and small (S) segments. Here, the sequence characterization of previously undescribed L and S segments from novel strains originating in the Middle East and Africa is reported. Further scrutiny of this data with phylogenetic tools, in the context of other publicly available sequence information, reveals analogous grouping patterns between the L and S segments. These groups correlate with the geographical distribution of strain isolation and indicate that the L and S segments of CCHF viruses have evolved together.
UR - http://www.scopus.com/inward/record.url?scp=28044460066&partnerID=8YFLogxK
U2 - 10.1099/vir.0.81213-0
DO - 10.1099/vir.0.81213-0
M3 - Article
C2 - 16298979
AN - SCOPUS:28044460066
SN - 0022-1317
VL - 86
SP - 3337
EP - 3341
JO - Journal of General Virology
JF - Journal of General Virology
IS - 12
ER -