Clinical management of casualties exposed to lung damaging agents: A critical review

David Russell*, P. G. Blaine, P. Rice

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    31 Citations (Scopus)

    Abstract

    There is no specific antidote for the treatment of casualties exposed to chlorine, phosgene, or mustards; therefore, management is largely supportive. Corticosteroid treatment has been given to casualties accidentally exposed to chlorine. Clinical data on efficacy are inconclusive as the numbers given steroids have been small and the indications for administration unclear. There have been no clinical controlled studies. There is a stronger evidence base from animal studies, particularly from porcine and rodent models. Lung injury induced by phosgene and mustard appears to be mediated by glutathione depletion, lipid peroxidation, free radical generation, and subsequent cellular toxicity. There is limited evidence to suggest that repletion of glutathione reduces and/or prevents lung damage by these agents. This may provide an opportunity for therapeutic intervention.

    Original languageEnglish
    Pages (from-to)421-424
    Number of pages4
    JournalEmergency Medicine Journal
    Volume23
    Issue number6
    DOIs
    Publication statusPublished - Jun 2006

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