Clinical and Pathological Study of the First Outbreak Cases of African Swine Fever in Vietnam, 2019

Bui Thi To Nga, Bui Tran Anh Dao, Lan Nguyen Thi, Makoto Osaki, Kenji Kawashima, Daesub Song, Francisco J. Salguero, Van Phan Le*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


African swine fever (ASF) is a devastating disease of swine and the most important disease for the pork industry. Since the outbreaks in 2007 in the Caucasian region, it has been spreading to the West and East quite swiftly. In this study we have analyzed the clinical signs and pathological features of the first outbreaks on ASF in Vietnam in 2019, caused by an isolate with 100% similarity to the genotype II (p72) isolates from Georgia in 2007 and China in 2018. The disease onset with a peracute to acute clinical course with high mortality. Some animals showed very unspecific clinical signs with other showing severe hyperthermia, respiratory distress, diarrhea, or vomit. Hemorrhagic splenomegaly and lymphadenitis were the main lesions observed at post mortem examination, with histopathological changes confirming the lymphoid depletion and multiorganic hemorrhages. Monocyte-macrophages were identified by means of immunohistochemical methods as the main target cell for the ASF virus in tissue sections.

Original languageEnglish
Article number392
JournalFrontiers in Veterinary Science
Publication statusPublished - 8 Jul 2020

Bibliographical note

Publisher Copyright:
© Copyright © 2020 Nga, Tran Anh Dao, Nguyen Thi, Osaki, Kawashima, Song, Salguero and Le.


  • African swine fever
  • pathology
  • pig
  • porcine
  • virus


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