Abstract
Pertussis continues to be an important cause of morbidity and mortality in children too young to be fully protected despite high vaccination coverage. This has been attributed to waning immunity in older people, leading to the development of strategies to increase levels of immunity. A systematic review was conducted to assess the clinical and cost effectiveness of four population-based strategies for pertussis booster vaccination: single booster at 12-24 months old, single pre-school booster, single adolescent booster and multiple boosters in adulthood every 10 years. Electronic databases and Internet resources were searched to June 2006. Nine observational studies, four mathematical models and eight economic evaluations were included, evaluating four different strategies. Strong evidence to recommend any of these strategies was not found.
| Original language | English |
|---|---|
| Pages (from-to) | 6768-6776 |
| Number of pages | 9 |
| Journal | Vaccine |
| Volume | 26 |
| Issue number | 52 |
| DOIs | |
| Publication status | Published - 9 Dec 2008 |
Bibliographical note
Funding Information:This work was supported in part by the Juan Canalejo Foundation (A Coruña, Spain) and the Department of Public Health and Epidemiology, University of Birmingham, UK. We thank the following: lectures of the How to do a systematic review course (2006) from this department for methodological advice; Janine Dretzke for quality assesment and data extraction support; Josie Sandercock for language and critical review; Beatriz Nieto for comments on the manuscript; Marjolein Hemelt and Alejandra Aris for translations and Amanda Burls for making possible all the previous. Conflicts of interest: None.
Keywords
- Booster strategy
- Economic evaluation
- Pertussis vaccination
- Systematic review
