Abstract
Due to the diversity of the chemical forms of radionuclides inhaled in industry and the environment, the assessment of intake and dose is based frequently on biokinetic studies of the materials in laboratory animals. The ICRP respiratory tract and systemic models provide an effective framework for extrapolating the results of such studies to humans, but there is a paucity of data concerning the crucial assumption that the absorption rates from lungs into blood for a given material are independent of the mammalian species. To address this uncertainty, biokinetic studies involving five chemical compounds and four mammalian species are being conducted. The compounds, with the species in parenthesis, are Pu-nitrate (man, primate, rat), Gd-oxide (man, primate, dog, rat), Np- oxide and nitrate (primate, rat), and U-octoxide (primate, dog, rat). This paper describes progress to date.
| Original language | English |
|---|---|
| Pages (from-to) | 323-337 |
| Number of pages | 15 |
| Journal | Journal of Radioanalytical and Nuclear Chemistry Articles |
| Volume | 243 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2000 |
Bibliographical note
Funding Information:This paper is based primarily on work partially funded by the Commission of the European Communities under contract F14PCT0026. In addition we are indebted to the Nuclear Installations Inspectorate, Health and Safety Executive, UK, for supporting the human volunteer studies under contract NUC 56/383/1(035). The preparation of uranium octoxide and animal study carried out at LRRI, Albuquerque were carried under Agreement No DE-FCO4-96AL76406, Office of Biological and Environmental Research.
