Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV

Gurmit K. Jagjit Singh*, Samreen Ijaz, Neesha Rockwood, Simon P. Farnworth, Emma Devitt, Mark Atkins, Richard Tedder, Mark Nelson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)


Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent transaminitis which predated commencement of antiretroviral therapy. Hepatic elastography and liver biopsy revealed cirrhosis. In 2010, he tested positive for HEV IgM/IgG antibodies. Plasma HEV RNA was detected. Archived samples revealed HEV viraemia since 2000. A 24-week course of pegylated interferon was commenced and HEV RNA became undetectable at week 4 until week 27 post treatment cessation. Chronic HEV infection should be considered in HIV patients as a cause for unexplained transaminitis and cryptogenic liver cirrhosis.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalJournal of Infection
Issue number1
Publication statusPublished - Jan 2013


  • HIV
  • Hepatitis E
  • Immunosuppression
  • Liver
  • Pegylated interferon
  • Transaminitis


Dive into the research topics of 'Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV'. Together they form a unique fingerprint.

Cite this