Chronic excretion of a norovirus in a child with cartilage hair hypoplasia (CHH)

Christopher Gallimore*, David Lewis, Clive Taylor, Andrew Cant, Andrew Gennery, Jim J. Gray

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

We have demonstrated the long-term excretion of a stable recombinant norovirus in a patient with cartilage hair hypoplasia (CHH), with a T cell immunodeficiency, following bone marrow transplantation (BMT). The patient excreted an ARG320/1999/US-like recombinant norovirus (rGII-3) for 156 days during a period of immune reconstitution. The child was symptomatic during the period of virus shedding. It is not known if the child acquired the recombinant strain or if recombination occurred in vivo.

Original languageEnglish
Pages (from-to)196-204
Number of pages9
JournalJournal of Clinical Virology
Volume30
Issue number2
DOIs
Publication statusPublished - Jun 2004

Keywords

  • BMT
  • CHH
  • Norovirus
  • Recombinant
  • T cell immunodeficiency

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