Chromosome aberrations induced in human lymphocytes by D-T neutrons

D. C. Lloyd; Alan Edwards; J. S. Prosser; D. Bolton; A. G. Sherwin

doi:10.2307/3576488

Chromosome aberrations induced in human lymphocytes by D-T neutrons

D. C. Lloyd, Alan Edwards, J. S. Prosser, D. Bolton, A. G. Sherwin

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Abstract

Unstable chromosome aberrations induced by in vitro irradiation with D-T neutrons have been analyzed in human blood lymphocytes. With respect to 250 kVP X rays a maximum limiting RBE at low doses of 4.1 was obtained for dicentric aberrations. Using aberrations as markers in mixed cultures of irradiated and unirradiated cells permits an assessment of interphase death plus mitotic delay. The low-dose RBE for this effect is 2.5. Assuming all unstable aberrations observed at metaphase would lead to cell death by nondisjunction allows an assessment of mitotic death. The low-dose RBE for this effect is 4.5. The data are compared with similar work obtained earlier with ²⁴²Cm α particles. The application of the present work to cytogenetic assessment of dose after accidental exposure to D-T neutrons is discussed.

Original language	English
Pages (from-to)	561-573
Number of pages	13
Journal	Radiation Research
Volume	98
Issue number	3
DOIs	https://doi.org/10.2307/3576488
Publication status	Published - 1984

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abstract = "Unstable chromosome aberrations induced by in vitro irradiation with D-T neutrons have been analyzed in human blood lymphocytes. With respect to 250 kVP X rays a maximum limiting RBE at low doses of 4.1 was obtained for dicentric aberrations. Using aberrations as markers in mixed cultures of irradiated and unirradiated cells permits an assessment of interphase death plus mitotic delay. The low-dose RBE for this effect is 2.5. Assuming all unstable aberrations observed at metaphase would lead to cell death by nondisjunction allows an assessment of mitotic death. The low-dose RBE for this effect is 4.5. The data are compared with similar work obtained earlier with 242Cm α particles. The application of the present work to cytogenetic assessment of dose after accidental exposure to D-T neutrons is discussed.",

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T1 - Chromosome aberrations induced in human lymphocytes by D-T neutrons

AU - Lloyd, D. C.

AU - Edwards, Alan

AU - Prosser, J. S.

AU - Bolton, D.

AU - Sherwin, A. G.

PY - 1984

Y1 - 1984

N2 - Unstable chromosome aberrations induced by in vitro irradiation with D-T neutrons have been analyzed in human blood lymphocytes. With respect to 250 kVP X rays a maximum limiting RBE at low doses of 4.1 was obtained for dicentric aberrations. Using aberrations as markers in mixed cultures of irradiated and unirradiated cells permits an assessment of interphase death plus mitotic delay. The low-dose RBE for this effect is 2.5. Assuming all unstable aberrations observed at metaphase would lead to cell death by nondisjunction allows an assessment of mitotic death. The low-dose RBE for this effect is 4.5. The data are compared with similar work obtained earlier with 242Cm α particles. The application of the present work to cytogenetic assessment of dose after accidental exposure to D-T neutrons is discussed.

AB - Unstable chromosome aberrations induced by in vitro irradiation with D-T neutrons have been analyzed in human blood lymphocytes. With respect to 250 kVP X rays a maximum limiting RBE at low doses of 4.1 was obtained for dicentric aberrations. Using aberrations as markers in mixed cultures of irradiated and unirradiated cells permits an assessment of interphase death plus mitotic delay. The low-dose RBE for this effect is 2.5. Assuming all unstable aberrations observed at metaphase would lead to cell death by nondisjunction allows an assessment of mitotic death. The low-dose RBE for this effect is 4.5. The data are compared with similar work obtained earlier with 242Cm α particles. The application of the present work to cytogenetic assessment of dose after accidental exposure to D-T neutrons is discussed.

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JO - Radiation Research

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Chromosome aberrations induced in human lymphocytes by D-T neutrons

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