Chromosome aberrations induced in human lymphocytes by 8·7 mev protons and 23·5 mev helium-3 ions

A. A. Edwards*, D. C. Lloyd, J. S. Prosser, P. Finnon, J. E. Moquet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


This paper describes the irradiation of thin samples of blood with 8·7 MeV protons and 23·5 MeV helium-3 ions in the track segment mode. Chromosome aberrations in human lymphocytes have been scored. The relationship between dicentric yield and dose in Gy was Y = 0·044 D + 0·058 D2 for protons and Y = 0·394 D for helium ions. These results are compared with data from other laboratories using protons and an attempt is made to reconcile differences. An unexpected observation was that the ratio of the linear coefficients for helium ions and protons was about 9 whereas the ratio of the l.e.t. values was 4·5. This disagrees with current theory which predicts that the linear coefficients should be proportional to l.e.t. Possible sources of error in our experiments are discussed but do not adequately account for the discrepancies.

Original languageEnglish
Pages (from-to)137-145
Number of pages9
JournalInternational Journal of Radiation Biology
Issue number1
Publication statusPublished - 1986

Bibliographical note

Funding Information:
This work was partly supported by a CEC contract No. BIO/E/413/81 /UK. The contribution made by Mr F. Stewart and Mr E. Cartwright of Birmingham University who operated the Nuffield cyclotron and provided the necessary engineering to produce the particle beams is acknowledged. The help of Mr G. Wood and Mr S. Dean who respectively built the irradiation apparatus and constructed the electronic control circuitry is greatly appreciated.


  • Chromosome aberrations
  • Helium-3
  • Lymphocytes
  • Protons


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