Chromosomal radiosensitivity of lymphocytes from Alzheimer's disease patients

S. E. Tobi, Jayne Moquet, Alan Edwards, D. C. Lloyd, R. F. Itzhaki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

We have examined chromosome aberrations in λ irradiated (3 Gy) lymphocytes from five patients with Alzheimer's disease (AD). In each case, the number of dicentrics was significantly higher than the number in irradiated lymphocytes from five age matched normal subjects, the mean value for AD cells being about 25% higher. There was no significant difference in number of acentrics between AD and normal cells. Examination of the number of first, second, and third division meta-phases, using fluorescence plus Giemsa staining, indicated that there was no difference in cycling time between AD and normal cells, and that after irradiation both groups showed the same mitotic delay. The similarity of our findings to those of others with irradiated Down's syndrome cells (from adult patients) is discussed.

Original languageEnglish
Pages (from-to)437-440
Number of pages4
JournalJournal of Medical Genetics
Volume27
Issue number7
DOIs
Publication statusPublished - 1990

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