Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons

J. Pohl-Rüling, P. Fischer, D. C. Lloyd*, Alan Edwards, A. T. Natarajan, G. Obe, K. E. Buckton, N. O. Bianchi, P. P.W. van Buul, B. C. Das, F. Daschil, L. Fabry, M. Kučerová, A. Léonard, R. N. Mukherjee, U. Mukherjee, R. Nowotny, P. Palitti, Z. Polívková, T. SharmaW. Schmidt

*Corresponding author for this work

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19 Citations (Scopus)

Abstract

Unstable chromosome aberrations induced by in vitro irradiation with zero plus seven low doses of 14.8 MeV D-T neutrons in the range 3.55-244 mGy have been analysed in human peripheral blood lymphocytes. In order to obtain the required large numbers of scored cells for such low doses, fourteen laboratories participated in the experiment. The dose responses for dicentrics, excess acentrics and total aberrations, fitted well to the Y = αD model. The α coefficient of yield for dicentrics, 1.60 ± 0.07 × 10-2 Gy-1, compares well with the values obtained in previous studies with D-T neutrons at somewhat higher doses. Results from a previous collaborative study using 250 kVp X-rays over a comparable dose range indicated the possible existence of a threshold below 50 mGy. In the present study there is no clear evidence for neutrons for such a threshold. However, the data were insufficient to permit the rejection of a possible threshold below ∼ 10 mGy.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalMutation Research Letters
Volume173
Issue number4
DOIs
Publication statusPublished - Apr 1986

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