Choice of nebulisers and compressors for delivery of carbenicillin aerosol

S. P. Newman, P. G.D. Pellow, S. W. Clarke

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Although aerosol antibiotics have been used successfully to treat respiratory tract infection in patients with cystic fibrosis, little information exists concerning the correct nebulisation technique for antibiotic solutions. We have measured aerosol output, droplet size and nebulisation time for 1 g carbenicillin (Pyopen, Beechams) diluted with 3 ml of 4 ml water for injection and delivered from six brands of ject nebuliser (Cirrus, DeVilbiss, Inspiron, Turret, Unicorn and Upmist). Three relatively weak compressors (Medix Traveller, Medic-Aid PortaNeb 50 and Inspiron) and three more powerful compressors (Medix WOBL, Medix Maxi mark I and Gast) were used as driving sources. Maxi and Gast compressors increased the quantity of 'respirable' (<5 μm diameter) carbenicillin aerosol, and reduced nebulisation times; with the weaker compressors, nebulisation times (up to 50 min) were unacceptably long. The Turret nebuliser proved to be the most efficient, but several other brands would also be acceptable if used with a powerful compressor.

Original languageEnglish
Pages (from-to)160-168
Number of pages9
JournalEuropean Journal of Respiratory Diseases
Issue number3
Publication statusPublished - 1986
Externally publishedYes


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