Childhood hemolytic uremic syndrome, United Kingdom and Ireland

Richard M. Lynn; Sarah J. O'Brien; C. Mark Taylor; Goutam K. Adak; Henrik Chart; Thomas Cheasty; John E. Coia; Iain A. Gillespie; Mary E. Locking; William J. Reilly; Henry R. Smith; Aoife Waters; Geraldine A. Willshaw

doi:10.3201/eid1104.040833

Childhood hemolytic uremic syndrome, United Kingdom and Ireland

Richard M. Lynn, Sarah J. O'Brien^*, C. Mark Taylor, Goutam K. Adak, Henrik Chart, Thomas Cheasty, John E. Coia, Iain A. Gillespie, Mary E. Locking, William J. Reilly, Henry R. Smith, Aoife Waters, Geraldine A. Willshaw

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We conducted prospective surveillance of childhood hemolytic uremic syndrome (HUS) from 1997 to 2001 to describe disease incidence and clinical, epidemiologic and microbiologic characteristics. We compared our findings, where possible, with those of a previous study conducted from 1985 to 1988. The average annual incidence of HUS for the United Kingdom and Ireland (0.71/100,000) was unchanged from 1985 to 1988. The overall early mortality had halved, but the reduction in mortality was almost entirely accounted for by improved outcome in patients with diarrhea-associated HUS. The principal infective cause of diarrhea-associated HUS was Shiga toxin-producing Escherichia coli O157 (STEC O157), although in the 1997-2001 survey STEC O157 phage type (PT) 21/28 had replaced STEC O157 PT2 as the predominant PT. The risk of developing diarrhea-associated HUS was significantly higher in children infected with STEC O157 PT 2 and PT 21/28 compared with other PTs. Hypertension as a complication of HUS was greatly reduced in patients with diarrhea-associated HUS.

Original language	English
Pages (from-to)	590-596
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	11
Issue number	4
DOIs	https://doi.org/10.3201/eid1104.040833
Publication status	Published - Apr 2005

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title = "Childhood hemolytic uremic syndrome, United Kingdom and Ireland",

abstract = "We conducted prospective surveillance of childhood hemolytic uremic syndrome (HUS) from 1997 to 2001 to describe disease incidence and clinical, epidemiologic and microbiologic characteristics. We compared our findings, where possible, with those of a previous study conducted from 1985 to 1988. The average annual incidence of HUS for the United Kingdom and Ireland (0.71/100,000) was unchanged from 1985 to 1988. The overall early mortality had halved, but the reduction in mortality was almost entirely accounted for by improved outcome in patients with diarrhea-associated HUS. The principal infective cause of diarrhea-associated HUS was Shiga toxin-producing Escherichia coli O157 (STEC O157), although in the 1997-2001 survey STEC O157 phage type (PT) 21/28 had replaced STEC O157 PT2 as the predominant PT. The risk of developing diarrhea-associated HUS was significantly higher in children infected with STEC O157 PT 2 and PT 21/28 compared with other PTs. Hypertension as a complication of HUS was greatly reduced in patients with diarrhea-associated HUS.",

author = "Lynn, {Richard M.} and O'Brien, {Sarah J.} and Taylor, {C. Mark} and Adak, {Goutam K.} and Henrik Chart and Thomas Cheasty and Coia, {John E.} and Gillespie, {Iain A.} and Locking, {Mary E.} and Reilly, {William J.} and Smith, {Henry R.} and Aoife Waters and Willshaw, {Geraldine A.}",

year = "2005",

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doi = "10.3201/eid1104.040833",

language = "English",

volume = "11",

pages = "590--596",

journal = "Emerging Infectious Diseases",

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AU - O'Brien, Sarah J.

AU - Taylor, C. Mark

AU - Adak, Goutam K.

AU - Chart, Henrik

AU - Cheasty, Thomas

AU - Coia, John E.

AU - Gillespie, Iain A.

AU - Locking, Mary E.

AU - Reilly, William J.

AU - Smith, Henry R.

AU - Waters, Aoife

AU - Willshaw, Geraldine A.

PY - 2005/4

Y1 - 2005/4

N2 - We conducted prospective surveillance of childhood hemolytic uremic syndrome (HUS) from 1997 to 2001 to describe disease incidence and clinical, epidemiologic and microbiologic characteristics. We compared our findings, where possible, with those of a previous study conducted from 1985 to 1988. The average annual incidence of HUS for the United Kingdom and Ireland (0.71/100,000) was unchanged from 1985 to 1988. The overall early mortality had halved, but the reduction in mortality was almost entirely accounted for by improved outcome in patients with diarrhea-associated HUS. The principal infective cause of diarrhea-associated HUS was Shiga toxin-producing Escherichia coli O157 (STEC O157), although in the 1997-2001 survey STEC O157 phage type (PT) 21/28 had replaced STEC O157 PT2 as the predominant PT. The risk of developing diarrhea-associated HUS was significantly higher in children infected with STEC O157 PT 2 and PT 21/28 compared with other PTs. Hypertension as a complication of HUS was greatly reduced in patients with diarrhea-associated HUS.

AB - We conducted prospective surveillance of childhood hemolytic uremic syndrome (HUS) from 1997 to 2001 to describe disease incidence and clinical, epidemiologic and microbiologic characteristics. We compared our findings, where possible, with those of a previous study conducted from 1985 to 1988. The average annual incidence of HUS for the United Kingdom and Ireland (0.71/100,000) was unchanged from 1985 to 1988. The overall early mortality had halved, but the reduction in mortality was almost entirely accounted for by improved outcome in patients with diarrhea-associated HUS. The principal infective cause of diarrhea-associated HUS was Shiga toxin-producing Escherichia coli O157 (STEC O157), although in the 1997-2001 survey STEC O157 phage type (PT) 21/28 had replaced STEC O157 PT2 as the predominant PT. The risk of developing diarrhea-associated HUS was significantly higher in children infected with STEC O157 PT 2 and PT 21/28 compared with other PTs. Hypertension as a complication of HUS was greatly reduced in patients with diarrhea-associated HUS.

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AN - SCOPUS:20144386770

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JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

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ER -

Childhood hemolytic uremic syndrome, United Kingdom and Ireland

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