TY - JOUR
T1 - Characterization of toxigenic Corynebacterium ulcerans strains isolated from humans and domestic cats in the United Kingdom
AU - De Zoysa, Aruni
AU - Hawkey, Peter M.
AU - Engler, Kathy
AU - George, Robert
AU - Mann, Gina
AU - Reilly, William
AU - Taylor, David
AU - Efstratiou, Androulla
PY - 2005/9
Y1 - 2005/9
N2 - In the United Kingdom there has been a marked increase in the number of human infections caused by toxigenic Corynebacterium ulcerans. During 2002 and 2003 the organism was also isolated from several domestic cats with bilateral nasal discharge. As C. ulcerans has never previously been isolated from cats, the 16S rRNA gene from three cat isolates was sequenced to confirm their species identities. Fifty clinical isolates from the United Kingdom isolated from 1986 to 2003 and seven cat isolates were characterized by ribotyping to determine whether the ribotypes of the cat isolates were genotypically related to those found for human clinical isolates. For comparison, the genotypes of 11 overseas isolates and 13 isolates from H. R. Carne's collection isolated between 1933 and 1979 were also determined. Strains isolated from domestic cats were found to exhibit the predominant ribotypes observed among human clinical isolates, suggesting that C. ulcerans isolated from cats could be a potential reservoir for human infection.
AB - In the United Kingdom there has been a marked increase in the number of human infections caused by toxigenic Corynebacterium ulcerans. During 2002 and 2003 the organism was also isolated from several domestic cats with bilateral nasal discharge. As C. ulcerans has never previously been isolated from cats, the 16S rRNA gene from three cat isolates was sequenced to confirm their species identities. Fifty clinical isolates from the United Kingdom isolated from 1986 to 2003 and seven cat isolates were characterized by ribotyping to determine whether the ribotypes of the cat isolates were genotypically related to those found for human clinical isolates. For comparison, the genotypes of 11 overseas isolates and 13 isolates from H. R. Carne's collection isolated between 1933 and 1979 were also determined. Strains isolated from domestic cats were found to exhibit the predominant ribotypes observed among human clinical isolates, suggesting that C. ulcerans isolated from cats could be a potential reservoir for human infection.
UR - http://www.scopus.com/inward/record.url?scp=24744461908&partnerID=8YFLogxK
U2 - 10.1128/JCM.43.9.4377-4381.2005
DO - 10.1128/JCM.43.9.4377-4381.2005
M3 - Article
C2 - 16145080
AN - SCOPUS:24744461908
SN - 0095-1137
VL - 43
SP - 4377
EP - 4381
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 9
ER -