Characterization of sapoviruses collected in the United Kingdom from 1989 to 2004

Chris I. Gallimore*, Miren Iturriza-Gomara, David Lewis, David Cubitt, Hilary Cotterill, Jim J. Gray

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

A fecal archive containing 115 sapovirus (SaV) strains detected in samples collected from 15 outbreaks and 98 sporadic cases of gastroenteritis between 1989 and 2004 in the UK were characterized in order to determine the genomic diversity within SaV co-circulating in the human population. Strains were characterized by partial sequencing of the genes encoding the RNA-dependent RNA polymerase (RdRp) region and/or the polymerase/capsid (Pol/Cap) junction of the open reading frame (Orf) 1. Overall, SaV of genogroup I genotype 1 (GI 1) were the predominant strains circulating in the UK in each year between 1989 and 2004. During 2004, GII 1 was the predominant strain. These two SaV types accounted for 89.5% of the sporadic cases and outbreaks in the UK. The remaining cases were caused by six other SaV genotypes. On the basis of partial sequencing of the RdRp and capsid encoding genes of strains, which did not show sufficient homology to any of the currently recognized genotypes, we propose the inclusion of a presumptive fourth genotype within genogroup (GI 4).

Original languageEnglish
Pages (from-to)673-682
Number of pages10
JournalJournal of Medical Virology
Volume78
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Molecular diversity
  • Sapoviruses

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