TY - JOUR
T1 - Characterization of group B streptococci recovered from infants with invasive disease in England and Wales
AU - Weisner, Abbie M.
AU - Johnson, Alan
AU - Lamagni, Theresa
AU - Arnold, Eve
AU - Warner, Marina
AU - Heath, Paul T.
AU - Efstratiou, Androulla
N1 - Funding Information:
Financial support: Meningitis Research Foundation (grant 2/00).
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Group B streptococci (GBS) are a major cause of invasive disease in infants, with enhanced surveillance in England and Wales showing an incidence of 0.74 cases per 1000 live births and a mortality rate of 8%. Among 353 isolates obtained during enhanced surveillance, the predominant serotypes were III (48%), Ia (27%), and V (10%), and the remainder comprised Ib, II, IV, VI, and VII; 3% were not typable. Isolates from patients with early-onset disease had serotypes in (38%), Ia (32%), and V (13%), with late-onset disease having a higher incidence of type III (67%) strains. Patients infected with serotype in strains had a higher rate of meningitis, and those with type V strains had a higher mortality rate. Isolates were susceptible to penicillin and ampicillin, but 4% were resistant to erythromycin, and 91% were resistant to tetracycline. A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales.
AB - Group B streptococci (GBS) are a major cause of invasive disease in infants, with enhanced surveillance in England and Wales showing an incidence of 0.74 cases per 1000 live births and a mortality rate of 8%. Among 353 isolates obtained during enhanced surveillance, the predominant serotypes were III (48%), Ia (27%), and V (10%), and the remainder comprised Ib, II, IV, VI, and VII; 3% were not typable. Isolates from patients with early-onset disease had serotypes in (38%), Ia (32%), and V (13%), with late-onset disease having a higher incidence of type III (67%) strains. Patients infected with serotype in strains had a higher rate of meningitis, and those with type V strains had a higher mortality rate. Isolates were susceptible to penicillin and ampicillin, but 4% were resistant to erythromycin, and 91% were resistant to tetracycline. A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales.
UR - http://www.scopus.com/inward/record.url?scp=2342527765&partnerID=8YFLogxK
U2 - 10.1086/382881
DO - 10.1086/382881
M3 - Article
C2 - 15127328
AN - SCOPUS:2342527765
SN - 1058-4838
VL - 38
SP - 1203
EP - 1208
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 9
ER -
