Characterisation of norovirus strains in rural Ghanaian children with acute diarrhoea

George E. Armah; Christopher Gallimore; Fred N. Binka; Richard H. Asmah; Jonathan Green; Ucheoma Ugoji; Francis Anto; David Brown; James Gray

doi:10.1002/jmv.20722

Characterisation of norovirus strains in rural Ghanaian children with acute diarrhoea

George E. Armah^*, Christopher Gallimore, Fred N. Binka, Richard H. Asmah, Jonathan Green, Ucheoma Ugoji, Francis Anto, David Brown, James Gray

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The incidence of calicivirus infection in Ghana and many other African countries is not known. Thirteen (15.9%) of the 82 diarrhoeic stool samples tested for caliciviruses were positive for noroviruses (NoVs). NoVs were present in all age groups and were detected only during the diarrhoea peak that coincided with the peak rotavirus season. Ten (76.9%) of the NoV detected were genogroup II (GII) NoVs and the remaining three (23.1%) genogroup I (GI) NoVs. The predominant GII detected was GII-4 (60%, 6/10). Three of the GII NoVs were determined to be recombinants of GII-8/GII-14 as deduced from the sequencing of the region spanning the Orf1/2 junction. The GII genotypes formed four clusters with published GII sequences. The data shown enhances understanding of NoV diversity in Ghanaian children and demonstrate the global spread of distinct common genotypes to African countries.

Original language	English
Pages (from-to)	1480-1485
Number of pages	6
Journal	Journal of Medical Virology
Volume	78
Issue number	11
DOIs	https://doi.org/10.1002/jmv.20722
Publication status	Published - Nov 2006

Bibliographical note

Funding Information:
The present work was supported by the National Nature Science Foundation of China (50676046).

Keywords

Children
Diarrhoea
Ghana
Norovirus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.20722

Cite this

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title = "Characterisation of norovirus strains in rural Ghanaian children with acute diarrhoea",

abstract = "The incidence of calicivirus infection in Ghana and many other African countries is not known. Thirteen (15.9%) of the 82 diarrhoeic stool samples tested for caliciviruses were positive for noroviruses (NoVs). NoVs were present in all age groups and were detected only during the diarrhoea peak that coincided with the peak rotavirus season. Ten (76.9%) of the NoV detected were genogroup II (GII) NoVs and the remaining three (23.1%) genogroup I (GI) NoVs. The predominant GII detected was GII-4 (60%, 6/10). Three of the GII NoVs were determined to be recombinants of GII-8/GII-14 as deduced from the sequencing of the region spanning the Orf1/2 junction. The GII genotypes formed four clusters with published GII sequences. The data shown enhances understanding of NoV diversity in Ghanaian children and demonstrate the global spread of distinct common genotypes to African countries.",

keywords = "Children, Diarrhoea, Ghana, Norovirus",

author = "Armah, {George E.} and Christopher Gallimore and Binka, {Fred N.} and Asmah, {Richard H.} and Jonathan Green and Ucheoma Ugoji and Francis Anto and David Brown and James Gray",

note = "Funding Information: The present work was supported by the National Nature Science Foundation of China (50676046).",

year = "2006",

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doi = "10.1002/jmv.20722",

language = "English",

volume = "78",

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AU - Armah, George E.

AU - Gallimore, Christopher

AU - Binka, Fred N.

AU - Asmah, Richard H.

AU - Green, Jonathan

AU - Ugoji, Ucheoma

AU - Anto, Francis

AU - Brown, David

AU - Gray, James

N1 - Funding Information: The present work was supported by the National Nature Science Foundation of China (50676046).

PY - 2006/11

Y1 - 2006/11

N2 - The incidence of calicivirus infection in Ghana and many other African countries is not known. Thirteen (15.9%) of the 82 diarrhoeic stool samples tested for caliciviruses were positive for noroviruses (NoVs). NoVs were present in all age groups and were detected only during the diarrhoea peak that coincided with the peak rotavirus season. Ten (76.9%) of the NoV detected were genogroup II (GII) NoVs and the remaining three (23.1%) genogroup I (GI) NoVs. The predominant GII detected was GII-4 (60%, 6/10). Three of the GII NoVs were determined to be recombinants of GII-8/GII-14 as deduced from the sequencing of the region spanning the Orf1/2 junction. The GII genotypes formed four clusters with published GII sequences. The data shown enhances understanding of NoV diversity in Ghanaian children and demonstrate the global spread of distinct common genotypes to African countries.

AB - The incidence of calicivirus infection in Ghana and many other African countries is not known. Thirteen (15.9%) of the 82 diarrhoeic stool samples tested for caliciviruses were positive for noroviruses (NoVs). NoVs were present in all age groups and were detected only during the diarrhoea peak that coincided with the peak rotavirus season. Ten (76.9%) of the NoV detected were genogroup II (GII) NoVs and the remaining three (23.1%) genogroup I (GI) NoVs. The predominant GII detected was GII-4 (60%, 6/10). Three of the GII NoVs were determined to be recombinants of GII-8/GII-14 as deduced from the sequencing of the region spanning the Orf1/2 junction. The GII genotypes formed four clusters with published GII sequences. The data shown enhances understanding of NoV diversity in Ghanaian children and demonstrate the global spread of distinct common genotypes to African countries.

KW - Children

KW - Diarrhoea

KW - Ghana

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M3 - Article

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AN - SCOPUS:33749564358

SN - 0146-6615

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SP - 1480

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JO - Journal of Medical Virology

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IS - 11

ER -

Characterisation of norovirus strains in rural Ghanaian children with acute diarrhoea

Abstract

Bibliographical note

Keywords

UN SDGs

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