Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002

A. B. Gjini; James M. Stuart; D. A. Lawlor; K. A.V. Cartwright; H. Christensen; M. Ramsay; R. S. Heyderman

doi:10.1017/S0950268805005595

Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002

A. B. Gjini
, James M. Stuart^*
, D. A. Lawlor
, K. A.V. Cartwright
, H. Christensen
, M. Ramsay
, R. S. Heyderman

^*Corresponding author for this work

Public Health Programme Directorate Office

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/10⁵ to 0.31/10⁵ (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.

Original language	English
Pages (from-to)	567-569
Number of pages	3
Journal	Epidemiology and Infection
Volume	134
Issue number	3
DOIs	https://doi.org/10.1017/S0950268805005595
Publication status	Published - Jun 2006

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title = "Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002",

abstract = "We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/105 to 0.31/105 (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.",

author = "Gjini, \{A. B.\} and Stuart, \{James M.\} and Lawlor, \{D. A.\} and Cartwright, \{K. A.V.\} and H. Christensen and M. Ramsay and Heyderman, \{R. S.\}",

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AU - Gjini, A. B.

AU - Stuart, James M.

AU - Lawlor, D. A.

AU - Cartwright, K. A.V.

AU - Christensen, H.

AU - Ramsay, M.

AU - Heyderman, R. S.

PY - 2006/6

Y1 - 2006/6

N2 - We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/105 to 0.31/105 (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.

AB - We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/105 to 0.31/105 (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.

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AN - SCOPUS:33646151878

SN - 0950-2688

VL - 134

SP - 567

EP - 569

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 3

ER -

Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002

Abstract

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