Abstract
We compared cytomegalovirus (CMV)-specific interferon-γ (IFN-γ), interleukin 2 (IL-2), and CD154 CD4+ T cell responses of infants to those from chronically infected adults and from children aged 4-5 years. Magnitudes of the responses were similar, although coexpression of IFN-γ plus CD154 occurred more than coexpression of IFN-γ plus IL-2 or IL-2 plus CD154. Responses remained constant during infancy, although the proportion of IFN-γ-producing cells increased from infancy to adulthood. Most responding cells in infants were undifferentiated (i.e., CD27 +CD28+), although IFN-γ-producing cells were disproportionately CD27-. By 12 months after diagnosis, viremia was rarely detectable, indicating that CMV was controlled despite the slow development of CMV-specific CD4+ T cell responses.
| Original language | English |
|---|---|
| Pages (from-to) | 658-662 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 197 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Mar 2008 |
| Externally published | Yes |
Bibliographical note
Funding Information:1Medical Research Council Laboratories Gambia, Banjul, the Gambia; 2National Institute for Public Health and the Environment, Bilthoven, the Netherlands; 3Jefferiss Trust Laboratory, Imperial College London, and 4Immunisation Department, Health Protection Agency Centre for Infections, London, United Kingdom; 5Department of Pediatrics, Bronx Lebanon Hospital Center, Bronx, New York; and 6Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium
Funding Information:
Received 30 July 2007; accepted 25 September 2007; electronically published 20 February 2008. Potential conflicts of interest: none reported. Financial support: GSK Biologicals, the Medical Research Council (SCC885, L2003-4), and Fonds National de la Recherche Scientifique, Belgium (to A.M.). a Current affiliation: MLW Clinical Research Programme, Blantyre, Malawi. Reprints or correspondence: Prof. David Miles, MLW Clinical Research Programme, PO Box 30096, Chichiri, Blantyre 3, Malawi ([email protected]).
